To the Editor Visualization has played an extremely important role in the current genomic revolution to inspect and understand variants, expression patterns, evolutionary changes, and a number of other relationships 1–3 . However, most of the information in read-to-reference or genome-genome alignments is lost for structural variations in the one-dimensional views of most genome browsers showing only reference coordinates. Instead, structural variations captured by long reads or assembled contigs often need more context to understand, including alignments and other genomic information from multiple chromosomes
Motivation: The accumulation of genome sequences will only accelerate in the coming years. We aim to...
Background An important aspect of cancer research is identifying inherited genetic variants that cau...
Here are the genome alignments resulting from "Split-alignment of genomes finds orthologies more acc...
Motivation: The number of completely sequenced genomes is continuously rising, allowing for comparat...
Background: Genomic duplications constitute major events in the evolution of species, allowing paral...
Identifying large-scale structural variation in cancer genomes continues to be a challenge to resear...
Large-scale genomics projects such as the Cancer Genome Atlas (TCGA), and the Encyclopedia of DNA El...
Motivation: Accurate alignments between entire genomes are crucial for comparative genomics. However...
Motivation: Researchers now have access to large volumes of genome sequences for comparative analysi...
Multiple sequence alignment (MSA) is essential for understanding genetic variations controlling phen...
Alignments of multiple genomes are a cornerstone of comparative genomics, but generating these align...
Background: High-density tiling arrays and new sequencing technologies are generating rapidly increa...
The availability of the assembled mouse genome makes possible, for the first time, an alignment and...
Multiple sequence alignment (MSA) is essential for understanding genetic variations controlling phen...
Here the authors characterize structural variations (SVs) in a cohort of individuals with complex ge...
Motivation: The accumulation of genome sequences will only accelerate in the coming years. We aim to...
Background An important aspect of cancer research is identifying inherited genetic variants that cau...
Here are the genome alignments resulting from "Split-alignment of genomes finds orthologies more acc...
Motivation: The number of completely sequenced genomes is continuously rising, allowing for comparat...
Background: Genomic duplications constitute major events in the evolution of species, allowing paral...
Identifying large-scale structural variation in cancer genomes continues to be a challenge to resear...
Large-scale genomics projects such as the Cancer Genome Atlas (TCGA), and the Encyclopedia of DNA El...
Motivation: Accurate alignments between entire genomes are crucial for comparative genomics. However...
Motivation: Researchers now have access to large volumes of genome sequences for comparative analysi...
Multiple sequence alignment (MSA) is essential for understanding genetic variations controlling phen...
Alignments of multiple genomes are a cornerstone of comparative genomics, but generating these align...
Background: High-density tiling arrays and new sequencing technologies are generating rapidly increa...
The availability of the assembled mouse genome makes possible, for the first time, an alignment and...
Multiple sequence alignment (MSA) is essential for understanding genetic variations controlling phen...
Here the authors characterize structural variations (SVs) in a cohort of individuals with complex ge...
Motivation: The accumulation of genome sequences will only accelerate in the coming years. We aim to...
Background An important aspect of cancer research is identifying inherited genetic variants that cau...
Here are the genome alignments resulting from "Split-alignment of genomes finds orthologies more acc...