Peutz-Jeghers syndrome (PJS) is a well-described inherited syndrome, characterized by the development of gastrointestinal polyps and characteristic mucocutaneous freckling. PJS is an autosomal prevailing disease, due to genetic mutation on chromosome 19p, manifested by restricted mucocutaneous melanosis in association with gastrointestinal (GI) polyposis. The gene for PJS has recently been shown to be a serine/threonine kinase, known as LKB1 or STK11, which maps to chromosome subband 19p13.3. This gene has a putative coding region of 1302 bp, divided into nine exons, and acts as a tumor suppressor in the hamartomatous polyps of PJS patients and in the other neoplasms that develop in PJS patients. It is probable that these neoplasms develop ...
Abstract. Clinical features of Peutz-Jeghers syndrome (PJS), an autosomal dominant disorder, include...
Peutz-Jeghers syndrome (PJS) is an autosomal dominantly inherited disease characterized by multiple ...
Peutz-Jeghers syndrome (PJS) is caused by inactivating mutations of the LKB1 (STK11) serine/threonin...
Peutz-Jeghers syndrome (PJS) is a rare autosomal dominantly inherited disorder with variable express...
Germline mutations in the LKB1/STK11 tumour suppressor gene cause Peutz-Jeghers syndrome (PJS), a ra...
Peutz-Jeghers syndrome (PJS) is a dominantly inherited human disorder characterized by gastrointesti...
Peutz-Jeghers syndrome (PJS) is a dominantly inherited human disorder characterized by gastrointesti...
A potential tumor suppressor gene, STK11, encoding a serine threonine kinase, has recently been iden...
A potential tumor suppressor gene, STK11, encoding a serine threonine kinase, has recently been iden...
Abstract Background Peutz-Jeghers syndrome (PJS) is caused by mutations in the tumor suppressor gene...
Peutz-Jeghers syndrome (PJS) is an autosomal dominantly inherited disease characterized by hamartoma...
Peutz-Jeghers syndrome (PJS) is an autosomal dominant disease characterized by mucocutaneous pigment...
Germline mutations of the tumor suppressor gene LKB1/STK11 are responsible for the Peutz-Jeghers syn...
Germline mutations of the tumor suppressor gene LKB1/STK11 are responsible for the Peutz-Jeghers syn...
Germline mutations of the tumor suppressor gene LKB1/STK11 are responsible for the Peutz-Jeghers syn...
Abstract. Clinical features of Peutz-Jeghers syndrome (PJS), an autosomal dominant disorder, include...
Peutz-Jeghers syndrome (PJS) is an autosomal dominantly inherited disease characterized by multiple ...
Peutz-Jeghers syndrome (PJS) is caused by inactivating mutations of the LKB1 (STK11) serine/threonin...
Peutz-Jeghers syndrome (PJS) is a rare autosomal dominantly inherited disorder with variable express...
Germline mutations in the LKB1/STK11 tumour suppressor gene cause Peutz-Jeghers syndrome (PJS), a ra...
Peutz-Jeghers syndrome (PJS) is a dominantly inherited human disorder characterized by gastrointesti...
Peutz-Jeghers syndrome (PJS) is a dominantly inherited human disorder characterized by gastrointesti...
A potential tumor suppressor gene, STK11, encoding a serine threonine kinase, has recently been iden...
A potential tumor suppressor gene, STK11, encoding a serine threonine kinase, has recently been iden...
Abstract Background Peutz-Jeghers syndrome (PJS) is caused by mutations in the tumor suppressor gene...
Peutz-Jeghers syndrome (PJS) is an autosomal dominantly inherited disease characterized by hamartoma...
Peutz-Jeghers syndrome (PJS) is an autosomal dominant disease characterized by mucocutaneous pigment...
Germline mutations of the tumor suppressor gene LKB1/STK11 are responsible for the Peutz-Jeghers syn...
Germline mutations of the tumor suppressor gene LKB1/STK11 are responsible for the Peutz-Jeghers syn...
Germline mutations of the tumor suppressor gene LKB1/STK11 are responsible for the Peutz-Jeghers syn...
Abstract. Clinical features of Peutz-Jeghers syndrome (PJS), an autosomal dominant disorder, include...
Peutz-Jeghers syndrome (PJS) is an autosomal dominantly inherited disease characterized by multiple ...
Peutz-Jeghers syndrome (PJS) is caused by inactivating mutations of the LKB1 (STK11) serine/threonin...