Association of genomic domains in BRCA1 and BRCA2 with prostate cancer risk and aggressiveness
- Patel, V.L.
- Busch, E.L.
- Friebel, T.M.
- Cronin, A.
- Leslie, G.
- McGuffog, L.
- Adlard, J.
- Agata, S.
- Agnarsson, B.A.
- Ahmed, M.
- Aittomaki, K.
- Alducci, E.
- Andrulis, I.L.
- Arason, A.
- Arnold, N.
- Artioli, G.
- Arver, B.
- Auber, B.
- Azzollini, J.
- Balmana, J.
- Barkardottir, R.B.
- Barnes, D.R.
- Barroso, A.
- Barrowdale, D.
- Belotti, M.
- Benitez, J.
- Bertelsen, B.
- Blok, M.J.
- Bodrogi, I.
- Bonadona, V.
- Bonanni, B.
- Bondavalli, D.
- Boonen, S.E.
- Borde, J.
- Borg, A.
- Bradbury, A.R.
- Brady, A.
- Brewer, C.
- Brunet, J.
- Buecher, B.
- Buys, S.S.
- Cabezas-Camarero, S.
- Caldes, T.
- Caliebe, A.
- Caligo, M.A.
- Calvello, M.
- Campbell, I.G.
- Carnevali, I.
- Carrasco, E.
- Chan, T.L.
- Chu, A.T.W.
- Chung, W.K.
- Claes, K.B.M.
- Cook, J.
- Cortesi, L.
- Couch, F.J.
- Daly, M.B.
- Damante, G.
- Darder, E.
- Davidson, R.
- Hoya, M. de la
- Puppa, L. della
- Dennis, J.
- Diez, O.
- Ding, Y.C.
- Ditsch, N.
- Domchek, S.M.
- Donaldson, A.
- Dworniczak, B.
- Easton, D.F.
- Eccles, D.M.
- Eeles, R.A.
- Ehrencrona, H.
- Ejlertsen, B.
- Engel, C.
- Evans, D.G.
- Faivre, L.
- Faust, U.
- Feliubadalo, L.
- Foretova, L.
- Fostira, F.
- Fountzilas, G.
- Frost, D.
- Garcia-Barberan, V.
- Garre, P.
- Gauthier-Villars, M.
- Geczi, L.
- Gehrig, A.
- Gerdes, A.M.
- Gesta, P.
- Giannini, G.
- Glendon, G.
- Godwin, A.K.
- Goldgar, D.E.
- Greene, M.H.
- Gutierrez-Barrera, A.M.
- Hahnen, E.
- Hamann, U.
- Hauke, J.
- Herold, N.
- Hogervorst, F.B.L.
- Honisch, E.
- Hopper, J.L.
- Hulick, P.J.
- Izatt, L.
- Jager, A.
- James, P.
- Janavicius, R.
- Jensen, U.B.
- Jensen, T.D.
- Johannsson, O.T.
- John, E.M.
- Joseph, V.
- Kang, E.
- Kast, K.
- Kiiski, J.I.
- Kim, S.W.
- Kim, Z.
- Ko, K.P.
- Konstantopoulou, I.
- Kramer, G.
- Krogh, L.
- Kruse, T.A.
- Kwong, A.
- Larsen, M.
- Lasset, C.
- Lautrup, C.
- Lazaro, C.
- Lee, J.
- Lee, J.W.
- Lee, M.H.
- Lemke, J.
- Lesueur, F.
- Liljegren, A.
- Lindblom, A.
- Llovet, P.
- Lopez-Fernandez, A.
- Lopez-Perolio, I.
- Lorca, V.
- Loud, J.T.
- Ma, E.S.K.
- Mai, P.L.
- Manoukian, S.
- Mari, V.
- Martin, L.
- Matricardi, L.
- Mebirouk, N.
- Medici, V.
- Meijers-Heijboer, H.E.J.
- Meindl, A.
- Mensenkamp, A.R.
- Miller, C.
- Gomes, D.M.
- Montagna, M.
- Mooij, T.M.
- Moserle, L.
- Mouret-Fourme, E.
- Mulligan, A.M.
- Nathanson, K.L.
- Navratilova, M.
- Nevanlinna, H.
- Niederacher, D.
- Nielsen, F.C.C.
- Nikitina-Zake, L.
- Offit, K.
- Olah, E.
- Olopade, O.I.
- Ong, K.R.
- Osorio, A.
- Ott, C.E.
- Palli, D.
- Park, S.K.
- Parsons, M.T.
- Pedersen, I.S.
- Peissel, B.
- Peixoto, A.
- Perez-Segura, P.
- Peterlongo, P.
- Petersen, A.H.
- Porteous, M.E.
- Pujana, M.A.
- Radice, P.
- Ramser, J.
- Rantala, J.
- Rashid, M.U.
- Rhiem, K.
- Rizzolo, P.
- Robson, M.E.
- Rookus, M.A.
- Rossing, C.M.
- Ruddy, K.J.
- Santos, C.
- Saule, C.
- Scarpitta, R.
- Schmutzler, R.K.
- Schuster, H.
- Senter, L.
- Seynaeve, C.M.
- Shah, P.D.
- Sharma, P.
- Shin, V.Y.
- Silvestri, V.
- Simard, J.
- Singer, C.F.
- Skytte, A.B.
- Snape, K.
- Solano, A.R.
- Soucy, P.
- Southey, M.C.
- Spurdle, A.B.
- Steele, L.
- Steinemann, D.
- Stoppa-Lyonnet, D.
- Stradella, A.
- Sunde, L.
- Sutter, C.
- Tan, Y.Y.
- Teixeira, M.R.
- Teo, S.H.
- Thomassen, M.
- Tibiletti, M.G.
- Tischkowitz, M.
- Tognazzo, S.
- Toland, A.E.
- Tommasi, S.
- Torres, D.
- Toss, A.
- Trainer, A.H.
- Tung, N.
- Asperen, C.J. van
- Baan, F.H. van der
- Kolk, L.E. van der
- Luijt, R.B. van der
- Hest, L.P. van
- Varesco, L.
- Varon-Mateeva, R.
- Viel, A.
- Vierstrate, J.
- Villa, R.
- Wachenfeldt, A. von
- Wagner, P.
- Wang-Gohrke, S.
- Wappenschmidt, B.
- Weitzel, J.N.
- Wieme, G.
- Yadav, S.
- Yannoukakos, D.
- Yoon, S.Y.
- Zanzottera, C.
- Zorn, K.K.
- D'Amico, A.V.
- Freedman, M.L.
- Pomerantz, M.M.
- Chenevix-Trench, G.
- Antoniou, A.C.
- Neuhausen, S.L.
- Ottini, L.
- Nielsen, H.R.
- Rebbeck, T.R.
- GEMO Study Collaborators
- EMBRACE Collaborators
- KConFab Investigators
- HEBON Investigators
Publication date
February 2020
DOI Publisher
American Association for Cancer Research (AACR)Abstract
Pathogenic sequence variants (PSV) in BRCA1 or BRCA2 (BRCA1/2) are associated with increased risk and severity of prostate cancer. Weevaluated whether PSVs inBRCA1/2 were associated with risk of overall prostate cancer or high grade (Gleason 8+) prostate cancer using an international sample of 65 BRCA1 and 171 BRCA2 male PSV carriers with prostate cancer, and 3,388 BRCA1 and 2,880 BRCA2 male PSV carriers without prostate cancer. PSVs in the 30 region of BRCA2 (c.7914+) were significantly associated with elevated risk of prostate cancer compared with reference bin c.1001c.7913 [HR = 1.78; 95% confidence interval (CI), 1.25-2.52; P = 0.001], as well as elevated risk of Gleason 8+ prostate cancer (HR = 3.11; 95% CI, 1.63-5.95; P = 0.001). c.75...
Add to ORKG