Outcome of children relapsing after first allogeneic haematopoietic stem cell transplantation for acute myeloid leukaemia: a retrospective I-BFM analysis of 333 children
- Uden, T.
- Bertaina, A.
- Abrahamsson, J.
- Ansari, M.
- Balduzzi, A.
- Bourquin, J.
- Gerhardt, C.
- Bierings, M.
- Hasle, H.
- Lankester, A.
- Mischke, K.
- Moore, A.S.
- Nivison-Smith, I.
- Pieczonka, A.
- Peters, C.
- Sedlacek, P.
- Reinhardt, D.
- Stein, J.
- Versluys, B.
- Wachowiak, J.
- Willems, L.
- Zimmermann, M.
- Locatelli, F.
- Sauer, M.G.
DOIAbstract
Outcome of 333 children with acute myeloid leukaemia relapsing after a first allogeneic haematopoietic stem cell transplantation was analyzed. Four-year probability of overall survival (4y-pOS) was 14%. 4y-pOS for 122 children receiving a second haematopoietic stem cell transplantation was 31% and 3% for those that did not (P = <0 center dot 0001). Achievement of a subsequent remission impacted survival (P = <0 center dot 0001). For patients receiving a second transplant survival with or without achieving a subsequent remission was comparable. Graft source (bone marrow vs. peripheral blood stem cells, P = 0 center dot 046) and donor choice (matched family vs. matched unrelated donor, P = 0 center dot 029) positively impacted survival after ...
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