Rapid dose-dependent Natural Killer (NK) cell modulation and cytokine responses following human rVSV-ZEBOV Ebolavirus vaccination
- Pejoski, D.
- Rham, C. de
- Martinez-Murillo, P.
- Santoro, F.
- Auderset, F.
- Medaglini, D.
- Pozzi, G.
- Vono, M.
- Lambert, P.H.
- Huttner, A.
- Haks, M.C.
- Ottenhoff, T.H.M.
- Villard, J.
- Siegrist, C.A.
- VEBCON Consortium
- VSV-EBOVAC Consortium
- VSV-EBOPLUS Consortium
Publication date
April 2020
DOI Publisher
Springer Science and Business Media LLCAbstract
The rVSV-ZEBOV Ebolavirus vaccine confers protection within days after immunization, suggesting the contribution of innate immune responses. We report modulation of rVSV-ZEBOV vaccinee blood CD56(+) NK cell numbers, NKG2D or NKp30 surface receptor expression, Killer Immunoglobulin-like Receptor (KIR)(+) cell percentages and NK-cell-related genes on day 1 post immunization. Inverse correlations existed between the concentration of several plasma cytokines and inhibitory KIR+ CD56(dim) or cytokine-responsive CD56(bright) NK cells. Thus, NK cells may contribute to the early protective efficacy of rVSV-ZEBOV in humans.Immunogenetics and cellular immunology of bacterial infectious disease
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