Smoking-by-genotype interaction in type 2 diabetes risk and fasting glucose
- Wu, P.T.
- Rybin, D.
- Bielak, L.F.
- Feitosa, M.F.
- Franceschini, N.
- Li, Y.Z.
- Lu, Y.C.
- Marten, J.
- Musani, S.K.
- Noordam, R.
- Raghavan, S.
- Rose, L.M.
- Schwander, K.
- Smith, A.V.
- Tajuddin, S.M.
- Vojinovic, D.
- Amin, N.
- Arnett, D.K.
- Bottinger, E.P.
- Demirkan, A.
- Florez, J.C.
- Ghanbari, M.
- Harris, T.B.
- Launer, L.J.
- Liu, J.M.
- Liu, J.
- Mook-Kanamori, D.O.
- Murray, A.D.
- Nalls, M.A.
- Peyser, P.A.
- Uitterlinden, A.G.
- Voortman, T.
- Bouchard, C.
- Chasman, D.
- Correa, A.
- Mutsert, R. de
- Evans, M.K.
- Gudnason, V.
- Hayward, C.
- Kao, L.D.
- Kardia, S.L.R.
- Kooperberg, C.
- Loos, R.J.F.
- Province, M.M.
- Rankinen, T.
- Redline, S.
- Ridker, P.M.
- Rotter, J.I.
- Siscovick, D.
- Smith, B.H.
- Duijn, C. van
- Zonderman, A.B.
- Rao, D.C.
- Wilson, J.G.
- Dupuis, J.
- Meigs, J.B.
- Liu, C.T.
- Vassy, J.L.
DOIAbstract
Smoking is a potentially causal behavioral risk factor for type 2 diabetes (T2D), but not all smokers develop T2D. It is unknown whether genetic factors partially explain this variation. We performed genome-environment-wide interaction studies to identify loci exhibiting potential interaction with baseline smoking status (ever vs. never) on incident T2D and fasting glucose (FG). Analyses were performed in participants of European (EA) and African ancestry (AA) separately. Discovery analyses were conducted using genotype data from the 50,000-single-nucleotide polymorphism (SNP) ITMAT-Broad-CARe (IBC) array in 5 cohorts from from the Candidate Gene Association Resource Consortium (n = 23,189). Replication was performed in up to 16 studies fro...
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