Common genetic variation indicates separate causes for periventricular and deep white matter hyperintensities
- Armstrong, N.J.
- Mather, K.A.
- Sargurupremraj, M.
- Knol, M.J.
- Malik, R.
- Satizabal, C.L.
- Yanek, L.R.
- Wen, W.
- Gudnason, V.G.
- Dueker, N.D.
- Elliott, L.T.
- Hofer, E.
- Bis, J.
- Jahanshad, N.
- Li, S.
- Logue, M.A.
- Luciano, M.
- Scholz, M.
- Smith, A.V.
- Trompet, S.
- Vojinovic, D.
- Xia, R.
- Alfaro-Almagro, F.
- Ames, D.
- Amin, N.
- Amouyel, P.
- Beiser, A.S.
- Brodaty, H.
- Deary, I.J.
- Fennema-Notestine, C.
- Gampawar, P.G.
- Gottesman, R.
- Griffanti, L.
- Jack, C.R.
- Jenkinson, M.
- Jiang, J.Y.
- Kral, B.G.
- Kwok, J.B.
- Lampe, L.
- Liewald, D.C.M.
- Maillard, P.
- Marchini, J.
- Bastin, M.E.
- Mazoyer, B.
- Pirpamer, L.
- Romero, J.R.
- Roshchupkin, G.V.
- Schofield, P.R.
- Schroeter, M.L.
- Stott, D.J.
- Thalamuthu, A.
- Trollor, J.
- Tzourio, C.
- Grond, J. van der
- Vernooij, M.W.
- Witte, V.A.
- Wright, M.J.
- Yang, Q.O.
- Morris, Z.
- Siggurdsson, S.
- Psaty, B.
- Villringer, A.
- Schmidt, H.
- Haberg, A.K.
- Duijn, C.M. van
- Jukema, J.W.
- Dichgans, M.
- Sacco, R.L.
- Wright, C.B.
- Kremen, W.S.
- Becker, L.C.
- Thompson, P.M.
- Mosley, T.H.
- Wardlaw, J.M.
- Ikram, M.A.
- Adams, H.H.H.
- Seshadri, S.
- Sachdev, P.S.
- Smith, S.M.
- Launer, L.
- Longstreth, W.
- DeCarli, C.
- Schmidt, R.
- Fornage, M.
- Debette, S.
- Nyquist, P.A.
DOIAbstract
Background and Purpose: Periventricular white matter hyperintensities (WMH; PVWMH) and deep WMH (DWMH) are regional classifications of WMH and reflect proposed differences in cause. In the first study, to date, we undertook genome-wide association analyses of DWMH and PVWMH to show that these phenotypes have different genetic underpinnings. Methods: Participants were aged 45 years and older, free of stroke and dementia. We conducted genome-wide association analyses of PVWMH and DWMH in 26,654 participants from CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology), ENIGMA (Enhancing Neuro-Imaging Genetics Through Meta-Analysis), and the UKB (UK Biobank). Regional correlations were investigated using the genome-wide associatio...
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