Carotid intima-media thickness progression as surrogate marker for cardiovascular risk meta-analysis of 119 clinical trials involving 100 667 patients
- Willeit, P.
- Tschiderer, L.
- Allara, E.
- Reuber, K.
- Seekircher, L.
- Gao, L.
- Liao, X.M.
- Lonn, E.
- Gerstein, H.C.
- Yusuf, S.
- Brouwers, F.P.
- Asselbergs, F.W.
- Gilst, W. van
- Anderssen, S.A.
- Grobbee, D.E.
- Kastelein, J.J.P.
- Visseren, F.L.J.
- Ntaios, G.
- Hatzitolios, A.I.
- Savopoulos, C.
- Nieuwkerk, P.T.
- Stroes, E.
- Walters, M.
- Higgins, P.
- Dawson, J.
- Gresele, P.
- Guglielmini, G.
- Migliacci, R.
- Ezhov, M.
- Safarova, M.
- Balakhonova, T.
- Sato, E.
- Amaha, M.
- Nakamura, T.
- Kapellas, K.
- Jamieson, L.M.
- Skilton, M.
- Blumenthal, J.A.
- Hinderliter, A.
- Sherwood, A.
- Smith, P.J.
- Agtmael, M.A. van
- Reiss, P.
- Vonderen, M.G.A. van
- Kiechl, S.
- Klingenschmid, G.
- Sitzer, M.
- Stehouwer, C.D.A.
- Uthoff, H.
- Zou, Z.Y.
- Cunha, A.R.
- Neves, M.F.
- Witham, M.D.
- Park, H.W.
- Lee, M.S.
- Bae, J.H.
- Bernal, E.
- Wachtell, K.
- Kjeldsen, S.E.
- Olsen, M.H.
- Preiss, D.
- Sattar, N.
- Beishuizen, E.
- Huisman, M.V.
- Espeland, M.A.
- Schmidt, C.
- Agewall, S.
- Ok, E.
- Asci, G.
- Groot, E. de
- Grooteman, M.P.C.
- Blankestijn, P.J.
- Bots, M.L.
- Sweeting, M.J.
- Thompson, S.G.
- Lorenz, M.W.
- PROG-IMT Proof-ATHERO Study Grp
DOIAbstract
Background: To quantify the association between effects of interventions on carotid intima-media thickness (cIMT) progression and their effects on cardiovascular disease (CVD) risk. Methods: We systematically collated data from randomized, controlled trials. cIMT was assessed as the mean value at the common-carotid-artery; if unavailable, the maximum value at the common-carotid-artery or other cIMT measures were used. The primary outcome was a combined CVD end point defined as myocardial infarction, stroke, revascularization procedures, or fatal CVD. We estimated intervention effects on cIMT progression and incident CVD for each trial, before relating the 2 using a Bayesian meta-regression approach. Results: We analyzed data of 119 randomiz...
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