Tiolazione di idrossipropil-β-ciclodestrina per applicazione oculare, caratterizzazione in vitro e in vivo

PISTOLESI, ALESSIA

Publication date

April 2091

Publisher

Pisa University Press

Abstract

The ocular administration of actives is still a challenge. In fact, eye drops ocular bioavailability is very low due to the small absorption surface, the dilution effect in the tear fluid and the rapid removal after blinking reflex. It has been shown that active with 2 <LogP <3 mostly have higher permeation; they tend to be administrated as suspensions because of their poor solubility in water, thus causing frequent redness and irritation. To overcome this problem, we synthetized a mucoadhesive cyclodextrin capable to form inclusion complex, able to increase the ocular residence time, the apparent solubility and the stability of lipophilic active principles. Briefly, in this thesis work we performed synthesis and characterization of thiolat...

Extracted data

We use cookies to provide a better user experience.

Data Protection

Tiolazione di idrossipropil-β-ciclodestrina per applicazione oculare, caratterizzazione in vitro e in vivo

Abstract

Extracted data

Tiolazione di idrossipropil-β-ciclodestrina per applicazione oculare, caratterizzazione in vitro e in vivo

Abstract

Extracted data

Related items

Related items