Epigenome-wide meta-analysis of DNA methylation and childhood asthma
- Reese, SE
- Xu, C-J
- den Dekker, HT
- Lee, MK
- Sikdar, S
- Ruiz-Arenas, C
- Merid, SK
- Rezwan, FI
- Page, CM
- Ullemar, V
- Melton, PE
- Oh, SS
- Yang, IV
- Burrows, K
- Soderhall, C
- Jima, DD
- Gao, L
- Arathimos, R
- Kupers, LK
- Wielscher, M
- Rzehak, P
- Lahti, J
- Laprise, C
- Madore, A-M
- Ward, J
- Bennett, BD
- Wang, T
- Bell, DA
- Vonk, JM
- Haberg, SE
- Zhao, S
- Karlsson, R
- Hollams, E
- Hu, D
- Richards, AJ
- Bergstrom, A
- Sharp, GC
- Felix, JF
- Bustamante, M
- Gruzieva, O
- Maguire, RL
- Gilliland, F
- Baiz, N
- Nohr, EA
- Corpeleijn, E
- Sebert, S
- Karmaus, W
- Grote, V
- Kajantie, E
- Magnus, MC
- Ortqvist, AK
- Eng, C
- Liu, AH
- Kull, I
- Jaddoe, VWV
- Sunyer, J
- Kere, J
- Hoyo, C
- Annesi-Maesano, I
- Arshad, SH
- Koletzko, B
- Brunekreef, B
- Binder, EB
- Raikkonen, K
- Reischl, E
- Holloway, JW
- Jarvelin, M-R
- Snieder, H
- Kazmi, N
- Breton, CV
- Murphy, SK
- Pershagen, G
- Anto, JM
- Relton, CL
- Schwartz, DA
- Burchard, EG
- Huang, R-C
- Nystad, W
- Almqvist, C
- Henderson, AJ
- Melen, E
- Duijts, L
- Koppelman, GH
- London, SJ
DOIAbstract
Background: Epigenetic mechanisms, including methylation, can contribute to childhood asthma. Identifying DNA methylation profiles in asthmatic patients can inform disease pathogenesis.Objective: We sought to identify differential DNA methylation in newborns and children related to childhood asthma.Methods: Within the Pregnancy And Childhood Epigenetics consortium, we performed epigenome-wide meta-analyses of school-age asthma in relation to CpG methylation (Illumina450K) in blood measured either in newborns, in prospective analyses, or cross-sectionally in school-aged children. We also identified differentially methylated regions.Results: In newborns (8 cohorts, 668 cases), 9 CpGs (and 35 regions) were differentially methylated (epigenome-...
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