Formulasi tablet ekstrak kunyit ( Curcuma longa l) sebagai kandidat anti demensia (Turmeric extract tablet formulation (curcuma longa l) for anti-dementia Candidate)

Turmeric (Curcuma longa L) is herbal plant that is generally used as a seasoning that can provide a savory taste and attractive color. In addition, turmeric is also applied in medicine because it has bioactive compound such as curcumin that acts as antioxidant, inflammation, and neuro-protector for dementia. The aims of this research are to formulate the turmeric extract tablet that meets the standard physical tests using the wet granulation method. Turmeric extract tablet formulations is made into three formulas (F1,F2 and F3), where the composition of aerosol, lactose, gelatin, and distilled water of the three formulas is designed by considering the results of the test parameter of turmeric exctract tablets in sequence.The printed turmeric extract tablets were tested by using disintegration tester, dual friability tester and hardness tester to evaluate the disintegration time, brittleness, hardness, and weight uniformity and size uniformity tests. The turmeric extract tablet with formulation F3 was composed of turmeric extract (15 g), aerosol (35 g), lactose (12.8 g), gelatin (0.5 g), magnesium stearate (1%) and deionized water (200 ml) meets the requirements of the tablet standard physical test. The results of three times replication of the tablets were obtained the weight (0.616 ± 0.355 mg), diameter (1.334 ± 0.280 cm), thick (0.518 ± 0.039), friability (0.065 ± 0.074%), hardness (4.635 ± 0.234 kg) and disintegration time (9.918 ± 4.386). The turmeric extract tablet with the F3 formulation has met the tablet standard physical test. Keywords: Curcumin, Dementia, Turmeric Extract Tablets, Wet Granulatio