Stromal Expression of Heat-Shock Protein 27 Is Associated with Worse Clinical Outcome in Patients with Colorectal Cancer Lung Metastases
- Multhoff, Gabriele
- Schweiger, Thomas
- Nikolowsky, Christoph
- Starlinger, Patrick
- Traxler, Denise
- Zimmermann, Matthias
- Birner, Peter
- Hegedüs, Balazs
- Dome, Balazs
- Bergmann, Michael
- Mildner, Michael
- Klepetko, Walter
- Hoetzenecker, Konrad
- Ankersmit, Hendrik Jan
Publication date
January 2015
DOI Publisher
Public Library of Science (PLoS) ISSN
1932-6203 Citation count (estimate)
9Abstract
Pulmonary metastases are common in patients with primary colorectal cancer (CRC). Heat- shock protein 27 (Hsp27) is upregulated in activated fibroblasts during wound healing and systemically elevated in various diseases. Cancer-associated fibroblasts (CAFs) are also thought to play a role as prognostic and predictive markers in various malignancies includ- ing CRC. Surprisingly, the expression of Hsp27 has never been assessed in CAFs. There- fore we aimed to investigate the expression level of Hsp27 in CAFs and its clinical implications in patients with CRC lung metastases
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