Periictal heart rate variability analysis suggests long-term postictal autonomic disturbance in epilepsy
- Tóth, V.
- Hejjel, L.
- Fogarasi, A.
- Gyimesi, Cs.
- Orsi, G.
- Szűcs, A.
- Kovács, N.
- Komoly, S.
- Janszky, J.
- Ebner, A.
DOIAbstract
Background: One of the possible pathomechanisms of sudden death in epilepsy (SUDEP) is a postictal dysregulation of autonomic nervous system. We performed a heart rate variability (HRV) analysis of the periictal state to analyze whether a cardiac autonomic disturbance exists after an epileptic seizure. Methods: We included 31 periictal video–EEG–ECG recordings of 31 patients with epilepsy who had consecutively undergone pre-surgical evaluation. Nine generalized tonic-clonic (GTCS), 15 complex partial, and seven simple motor seizures were included. HRV was evaluated by analyzing 5-min-long ECG epochs, sampling from baseline, direct preictal, early-postictal (<15 min after the seizure), and late-postictal (5–6 h after the seizure) periods....
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