Fabrication of an electrochemical mesalazine sensor based on ZIF-67

This paper describes the application of ZIF-67 nanoparticles for carbon paste electrode (CPE) modification for sensitive voltammetric detection of mesalazine (MSA). The characterization of as-synthesized ZIF-67 nanoparticles was investigated by different techniques. Furthermore, the electrochemical behavior of the modified CPE (MCPE) was investigated using EIS (electrochemical impedance spectroscopy) and CV (cyclic voltammetry) methods. The results showed an irreversible oxidation peak for MSA around 0.540 V vs. the Ag/AgCl reference electrode. The curve of the peak current of differential pulse voltammetry (DPV) vs MSA concentration was linear in the range of 0.03�50 μM with a detection limit of 0.01 µM. The prepared sensor presents good repeatability with acceptable relative standard deviation (RSD) values. Finally, the prepared electrode was successfully used in human serum and urine as real samples. © 2020 Elsevier Lt