Endogenous opioids are derived from four related polypeptide precursors: proenkephalin (PENK), prodynorphin (PDYN), pronociceptin (PNOC) and proopiomelanocortin (POMC). In mammals PENK encodes for four copy of Met-enkephalin, one octapeptide Met-enkephalin-Arg-Gly-Leu, one heptapeptide Met-enkephalin-Arg-Phe and a single copy of Leu-enkephalin. Our detailed bioinformatic search on the existing PENK sequences revealed several atypical hexapeptide Met-enkephalins in different vertebrate animals. They are located either in the second enkephalin unit or in the seventh enkephalin core position at the C-terminus. Altogether four different hexapeptide sequences were obtained representing eleven animal species: Met-enkephalin-Arg(6) (YGGFMR) in the...
Three opioid peptide precursors have been isolated and characterized in endocrine and nervous tissue...
The bradykinin and neuropeptide Y (NPY) receptors belong to the superfamily of G-protein coupled rec...
Molecular cloning and DNA sequencing have yielded considerable structural information about proenkep...
Zebrafish is considered a model organism, not only for the study of the biological functions of vert...
In mammals the opioids Met-enkephalin and Leu-enkephalin are derived from a common precursor, proenk...
International audienceA full-length proenkephalin cDNA (accession number: AF232670) was cloned from ...
The distribution of various opioid peptides derived from proenkephalin A and B was studied in the br...
BACKGROUND: The opioid system is involved in reward and pain mechanisms and consists in mammals of f...
Immunohistochemical methods have been used to investigate the distribution of various opioid peptide...
The affinities of certain endogenous opioid peptides and related sequences for ¿, ¿ and k opiate rec...
At the present time there is evidence for two families of related peptides which act as ligands for ...
International audiencePeptide E is a 25-amino acid peptide derived from proenkephalin A that was ori...
and protein levels. PEPTIDES 5 " Suppl I, %17, 1984.--Three opioid peptide precursors have been...
International audienceA peptide derived from the posttranslational processing of proenkephalin A was...
Several peptide fragments are produced by proteolytic cleavage of the opioid peptide precursor proen...
Three opioid peptide precursors have been isolated and characterized in endocrine and nervous tissue...
The bradykinin and neuropeptide Y (NPY) receptors belong to the superfamily of G-protein coupled rec...
Molecular cloning and DNA sequencing have yielded considerable structural information about proenkep...
Zebrafish is considered a model organism, not only for the study of the biological functions of vert...
In mammals the opioids Met-enkephalin and Leu-enkephalin are derived from a common precursor, proenk...
International audienceA full-length proenkephalin cDNA (accession number: AF232670) was cloned from ...
The distribution of various opioid peptides derived from proenkephalin A and B was studied in the br...
BACKGROUND: The opioid system is involved in reward and pain mechanisms and consists in mammals of f...
Immunohistochemical methods have been used to investigate the distribution of various opioid peptide...
The affinities of certain endogenous opioid peptides and related sequences for ¿, ¿ and k opiate rec...
At the present time there is evidence for two families of related peptides which act as ligands for ...
International audiencePeptide E is a 25-amino acid peptide derived from proenkephalin A that was ori...
and protein levels. PEPTIDES 5 " Suppl I, %17, 1984.--Three opioid peptide precursors have been...
International audienceA peptide derived from the posttranslational processing of proenkephalin A was...
Several peptide fragments are produced by proteolytic cleavage of the opioid peptide precursor proen...
Three opioid peptide precursors have been isolated and characterized in endocrine and nervous tissue...
The bradykinin and neuropeptide Y (NPY) receptors belong to the superfamily of G-protein coupled rec...
Molecular cloning and DNA sequencing have yielded considerable structural information about proenkep...