While telomerase is best known as the enzyme that maintains telomeres in dividing cells a number of TERT (Telomerase Reverse Transcriptase) -related non-canonical functions have been described. These functions are implicated in tumour development and stress response and recently have also been demonstrated in the brain. In contrast to other cells and tissues, in the brain the telomerase RNA component TERC is downregulated early during development resulting in the loss of telomerase activity in most cells except for neural stem cells. In contrast, the presence of the telomerase protein TERT persists during lifetime in neurons of the human brain. Although we are far from understanding the role of telomerase in the brain, the review aims to su...
Telomerase is a ribonucleoprotein that adds telomeric DNA to the ends of linear chromosomes. It is ...
Recent evidence points to extra-telomeric, noncanonical roles for telomerase in regulating stem cell...
Maintenance of telomere length during cell division is dependent on the catalytic subunit telomerase...
Telomerase, a specialized ribonucleoprotein enzyme complex, maintains telomere length at the 3′ end ...
International audienceTelomerase plays a critical role in stem cell function and tissue regeneration...
studies on chromosome termini (telomeres) and their discovery of telomerase, the enzyme that syn-the...
The telomerase ribonucleoprotein complex has a pivotal role in regulating the proliferation and sene...
As cells replicate their DNA during mitosis, telomeres are shortened due to the inherent limitations...
Telomeres are nucleoprotein structures located at the ends of linear chromosomes. In most human adul...
Telomerase is an enzyme that maintains telomeres in dividing cells using a template on its inherent ...
Telomeres are linear guanine-rich DNA structures at the ends of chromosomes. The length of telomeric...
PhD ThesisTelomerase is best known for its nuclear telomere maintenance function via its enzymati...
Human telomerase holoenzyme consists of the catalytic component TERT and the template RNA TERC. Howe...
Telomerase is a specialized reverse transcriptase that extends and maintains the terminal ends of ch...
Telomeres are DNA-protein complexes at the ends of eukaryotic chromosomes that play an important rol...
Telomerase is a ribonucleoprotein that adds telomeric DNA to the ends of linear chromosomes. It is ...
Recent evidence points to extra-telomeric, noncanonical roles for telomerase in regulating stem cell...
Maintenance of telomere length during cell division is dependent on the catalytic subunit telomerase...
Telomerase, a specialized ribonucleoprotein enzyme complex, maintains telomere length at the 3′ end ...
International audienceTelomerase plays a critical role in stem cell function and tissue regeneration...
studies on chromosome termini (telomeres) and their discovery of telomerase, the enzyme that syn-the...
The telomerase ribonucleoprotein complex has a pivotal role in regulating the proliferation and sene...
As cells replicate their DNA during mitosis, telomeres are shortened due to the inherent limitations...
Telomeres are nucleoprotein structures located at the ends of linear chromosomes. In most human adul...
Telomerase is an enzyme that maintains telomeres in dividing cells using a template on its inherent ...
Telomeres are linear guanine-rich DNA structures at the ends of chromosomes. The length of telomeric...
PhD ThesisTelomerase is best known for its nuclear telomere maintenance function via its enzymati...
Human telomerase holoenzyme consists of the catalytic component TERT and the template RNA TERC. Howe...
Telomerase is a specialized reverse transcriptase that extends and maintains the terminal ends of ch...
Telomeres are DNA-protein complexes at the ends of eukaryotic chromosomes that play an important rol...
Telomerase is a ribonucleoprotein that adds telomeric DNA to the ends of linear chromosomes. It is ...
Recent evidence points to extra-telomeric, noncanonical roles for telomerase in regulating stem cell...
Maintenance of telomere length during cell division is dependent on the catalytic subunit telomerase...