Inflammatory correlated response in two lines of rabbit selected divergently for litter size environmental variability

[EN] Animal welfare is a priority objective for the livestock industry. Litter size environmental variability has been related to environmental sensitivity. A divergent selection experiment for environmental variance of litter size variance was carried out successfully in rabbits over thirteen generations. The low line showed a lower inflammatory response and susceptibility to infectious disorders than the high line. In conclusion, the decrease of environmental sensitivity seems to increase the adaptation of the animal to the environment, and thus, its welfare.This research was supported by Projects AGL2017-86083, C2-1-P and C2-2-P, funded by Ministerio de Ciencia e Innovacion (MIC)-Agencia Estatal de Investigacion (AEI) and el Fondo Europeo de Desarrollo Regional (FEDER) "Una manera de hacer Europa" and Project AICO/2019/169 funded by Valencia Regional Government.Beloumi, D.; Blasco Mateu, A.; Muelas, R.; Santacreu Jerez, MA.; García, MDLL.; Argente, M. (2020). Inflammatory correlated response in two lines of rabbit selected divergently for litter size environmental variability. Animals. 10(9):1-9. https://doi.org/10.3390/ani1009154019109BODIN, L., BOLET, G., GARCIA, M., GARREAU, H., LARZUL, C., & DAVID, I. (2010). Robustesse et canalisation : vision de généticiens. INRAE Productions Animales, 23(1), 11-22. doi:10.20870/productions-animales.2010.23.1.3281Broom, D. M. (2008). Welfare Assessment and Relevant Ethical Decisions: Key Concepts. Annual Review of Biomedical Sciences, 10(0). doi:10.5016/1806-8774.2008.v10pt79MORMEDE, P., BOISSEAU-SOWINSKI, L., CHIRON, J., DIEDERICH, C., EDDISON, J., GUICHET, J.-L., … MEUNIER-SALAÜN, M.-C. (2018). Bien-être animal : contexte, définition, évaluation. INRA Productions Animales, 31(2), 145-162. doi:10.20870/productions-animales.2018.31.2.2299Scrivo, R., Vasile, M., Bartosiewicz, I., & Valesini, G. (2011). Inflammation as «common soil» of the multifactorial diseases. Autoimmunity Reviews, 10(7), 369-374. doi:10.1016/j.autrev.2010.12.006Del Giudice, M., & Gangestad, S. W. (2018). Rethinking IL-6 and CRP: Why they are more than inflammatory biomarkers, and why it matters. Brain, Behavior, and Immunity, 70, 61-75. doi:10.1016/j.bbi.2018.02.013Lockwood, K. G., Marsland, A. L., Cohen, S., & Gianaros, P. J. (2016). Sex differences in the association between stressor-evoked interleukin-6 reactivity and C-reactive protein. Brain, Behavior, and Immunity, 58, 173-180. doi:10.1016/j.bbi.2016.07.001Haran, J., Gardiner, F., & Suner, S. (2012). Correlation of C-reactive protein to severity of symptoms in acute influenza A infection. Journal of Emergencies, Trauma, and Shock, 5(2), 149. doi:10.4103/0974-2700.96484Shrotriya, S., Walsh, D., Nowacki, A. S., Lorton, C., Aktas, A., Hullihen, B., … Estfan, B. (2018). Serum C-reactive protein is an important and powerful prognostic biomarker in most adult solid tumors. PLOS ONE, 13(8), e0202555. doi:10.1371/journal.pone.0202555Chen, W., Zheng, K. I., Liu, S., Yan, Z., Xu, C., & Qiao, Z. (2020). Plasma CRP level is positively associated with the severity of COVID-19. Annals of Clinical Microbiology and Antimicrobials, 19(1). doi:10.1186/s12941-020-00362-2Stoner, L., Lucero, A. A., Palmer, B. R., Jones, L. M., Young, J. M., & Faulkner, J. (2013). Inflammatory biomarkers for predicting cardiovascular disease. Clinical Biochemistry, 46(15), 1353-1371. doi:10.1016/j.clinbiochem.2013.05.070Iung, L. H. de S., Carvalheiro, R., Neves, H. H. de R., & Mulder, H. A. (2019). Genetics and genomics of uniformity and resilience in livestock and aquaculture species: A review. Journal of Animal Breeding and Genetics, 137(3), 263-280. doi:10.1111/jbg.12454Blasco, A., Martínez-Álvaro, M., García, M.-L., Ibáñez-Escriche, N., & Argente, M.-J. (2017). Selection for environmental variance of litter size in rabbits. Genetics Selection Evolution, 49(1). doi:10.1186/s12711-017-0323-4Argente, M. J., García, M. L., Zbyňovská, K., Petruška, P., Capcarová, M., & Blasco, A. (2019). Correlated response to selection for litter size environmental variability in rabbits’ resilience. Animal, 13(10), 2348-2355. doi:10.1017/s1751731119000302Leineweber, C., Müller, E., & Marschang, R. E. (2018). Blood reference intervals for rabbits (Oryctolagus cuniculus) from routine diagnostic samples. Tierärztliche Praxis Ausgabe K: Kleintiere / Heimtiere, 46(06), 393-398. doi:10.1055/s-0038-1677403Mbanasor, U. U., Anene, B. M., Chime, A. B., Nnaji, T. O., Eze, J. I., & Ezekwe, A. G. (2003). Haematology of normal and trypanosome infected Muturu cattle in southeastern Nigeria. Nigerian Journal of Animal Production, 30(2). doi:10.4314/njap.v30i2.3300Moore, D. M., Zimmerman, K., & Smith, S. A. (2015). Hematological Assessment in Pet Rabbits. Veterinary Clinics of North America: Exotic Animal Practice, 18(1), 9-19. doi:10.1016/j.cvex.2014.09.003García-Quirós, A., Arnau-Bonachera, A., Penadés, M., Cervera, C., Martínez-Paredes, E., Ródenas, L., … Pascual, J. J. (2014). A robust rabbit line increases leucocyte counts at weaning and reduces mortality by digestive disorder during fattening. Veterinary Immunology and Immunopathology, 161(3-4), 123-131. doi:10.1016/j.vetimm.2014.07.005Ma, T., & Gao, Y. (2020). New insights into roles of basophils in initiating T helper type 2 immunity. Chinese Herbal Medicines, 12(1), 14-18. doi:10.1016/j.chmed.2019.09.006Furze, R. C., & Rankin, S. M. (2008). Neutrophil mobilization and clearance in the bone marrow. Immunology, 125(3), 281-288. doi:10.1111/j.1365-2567.2008.02950.xMahgoub, O., Kadim, I. T., Tageldin, M. H., Al-Marzooqi, W. S., Khalaf, S. Q., & Ali, A. A. (2008). Clinical profile of sheep fed non-conventional feeds containing phenols and condensed tannins. Small Ruminant Research, 78(1-3), 115-122. doi:10.1016/j.smallrumres.2008.05.009Stilwell, G., de Carvalho, R. C., Lima, M. S., & Broom, D. M. (2009). Effect of caustic paste disbudding, using local anaesthesia with and without analgesia, on behaviour and cortisol of calves. Applied Animal Behaviour Science, 116(1), 35-44. doi:10.1016/j.applanim.2008.06.008Mainau, E., & Manteca, X. (2011). Pain and discomfort caused by parturition in cows and sows. Applied Animal Behaviour Science, 135(3), 241-251. doi:10.1016/j.applanim.2011.10.020Gladden, N., McKeegan, D., Viora, L., & Ellis, K. A. (2018). Postpartum ketoprofen treatment does not alter stress biomarkers in cows and calves experiencing assisted and unassisted parturition: a randomised controlled trial. Veterinary Record, 183(13), 414-414. doi:10.1136/vr.104913Webster, J. I., Tonelli, L., & Sternberg, E. M. (2002). Neuroendocrine Regulation of Immunity. Annual Review of Immunology, 20(1), 125-163. doi:10.1146/annurev.immunol.20.082401.104914Glaser, R., & Kiecolt-Glaser, J. K. (2005). Stress-induced immune dysfunction: implications for health. Nature Reviews Immunology, 5(3), 243-251. doi:10.1038/nri1571Tanaka, T., Narazaki, M., & Kishimoto, T. (2014). IL-6 in Inflammation, Immunity, and Disease. Cold Spring Harbor Perspectives in Biology, 6(10), a016295-a016295. doi:10.1101/cshperspect.a016295Mootoo, A., Stylianou, E., Arias, M., & Reljic, R. (2009). TNF-α in Tuberculosis: A Cytokine with a Split Personality. Inflammation & Allergy-Drug Targets, 8(1), 53-62. doi:10.2174/187152809787582543Bruunsgaard, H., Andersen-Ranberg, K., Jeune, B., Pedersen, A. N., Skinhoj, P., & Pedersen, B. K. (1999). A High Plasma Concentration of TNF- Is Associated With Dementia in Centenarians. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 54(7), M357-M364. doi:10.1093/gerona/54.7.m357Jialal, I., Devaraj, S., & Venugopal, S. K. (2004). C-Reactive Protein: Risk Marker or Mediator in Atherothrombosis? Hypertension, 44(1), 6-11. doi:10.1161/01.hyp.0000130484.20501.dfBaumeister, D., Akhtar, R., Ciufolini, S., Pariante, C. M., & Mondelli, V. (2015). Childhood trauma and adulthood inflammation: a meta-analysis of peripheral C-reactive protein, interleukin-6 and tumour necrosis factor-α. Molecular Psychiatry, 21(5), 642-649. doi:10.1038/mp.2015.67Markanday, A. (2015). Acute Phase Reactants in Infections: Evidence-Based Review and a Guide for Clinicians. Open Forum Infectious Diseases, 2(3). doi:10.1093/ofid/ofv098Rauw, W. M. (2012). Immune response from a resource allocation perspective. Frontiers in Genetics, 3. doi:10.3389/fgene.2012.00267Sharma, A., Tate, M., Mathew, G., Vince, J. E., Ritchie, R. H., & de Haan, J. B. (2018). Oxidative Stress and NLRP3-Inflammasome Activity as Significant Drivers of Diabetic Cardiovascular Complications: Therapeutic Implications. Frontiers in Physiology, 9. doi:10.3389/fphys.2018.00114Fan, J., Kitajima, S., Watanabe, T., Xu, J., Zhang, J., Liu, E., & Chen, Y. E. (2015). Rabbit models for the study of human atherosclerosis: From pathophysiological mechanisms to translational medicine. Pharmacology & Therapeutics, 146, 104-119. doi:10.1016/j.pharmthera.2014.09.009Zhao, X., Li, L., Li, X., Li, J., Wang, D., & Zhang, H. (2019). The Relationship between Serum Bilirubin and Inflammatory Bowel Disease. Mediators of Inflammation, 2019, 1-7. doi:10.1155/2019/5256460Inoguchi, T., Sonoda, N., & Maeda, Y. (2016). Bilirubin as an important physiological modulator of oxidative stress and chronic inflammation in metabolic syndrome and diabetes: a new aspect on old molecule. Diabetology International, 7(4), 338-341. doi:10.1007/s13340-016-0288-5Koenig, G., & Seneff, S. (2015). Gamma-Glutamyltransferase: A Predictive Biomarker of Cellular Antioxidant Inadequacy and Disease Risk. Disease Markers, 2015, 1-18. doi:10.1155/2015/818570Kim, W. R., Flamm, S. L., Di Bisceglie, A. M., & Bodenheimer, H. C. (2008). Serum activity of alanine aminotransferase (ALT) as an indicator of health and disease. Hepatology, 47(4), 1363-1370. doi:10.1002/hep.22109Dirksen, K., Verzijl, T., van den Ingh, T. S. G. A. M., Vernooij, J. C. M., van der Laan, L. J. W., Burgener, I. A., … Fieten, H. (2016). Hepatocyte-derived microRNAs as sensitive serum biomarkers of hepatocellular injury in Labrador retrievers. The Veterinary Journal, 211, 75-81. doi:10.1016/j.tvjl.2016.01.010Casto-Rebollo, C., Argente, M. J., García, M. L., Pena, R., & Ibáñez-Escriche, N. (2020). Identification of functional mutations associated with environmental variance of litter size in rabbits. Genetics Selection Evolution, 52(1). doi:10.1186/s12711-020-00542-