Elective Neck Dissection or Sentinel Lymph Node Biopsy in Early Stage Oral Cavity Cancer Patients: The Dutch Experience
- den Toom, Inne J.
- Boeve, Koos
- Lobeek, Daphne
- Bloemena, Elisabeth
- Donswijk, Maarten L.
- de Keizer, Bart
- Klop, W. Martin C.
- Leemans, C. Rene
- Willems, Stefan M.
- Takes, Robert P.
- Witjes, Max J. H.
- de Bree, Remco
DOIAbstract
Background: Sentinel lymph node biopsy (SLNB) has been introduced as a diagnostic staging modality for detection of occult metastases in patients with early stage oral cancer. Comparisons regarding accuracy to the routinely used elective neck dissection (END) are lacking in literature. Methods: A retrospective, multicenter cohort study included 390 patients staged by END and 488 by SLNB. Results: The overall sensitivity (84% vs. 81%,p= 0.612) and negative predictive value (NPV) (93%,p= 1.000) were comparable between END and SLNB patients. The END cohort contained more pT2 tumours (51%) compared to the SLNB cohort (23%) (p<0.001). No differences were found for sensitivity and NPV between SLNB and END divided by pT stage. In floor-of-mouth (F...
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