Hematopoietic Stem and Progenitor Cells Exhibit Stage-Specific Translational Programs via mTOR- and CDK1-Dependent Mechanisms
- Spevak, Christina C
- Elias, Harold K
- Kannan, Lavanya
- Ali, Mohamed A E
- Martin, Gaëlle H
- Selvaraj, Shanmugapriya
- Eng, William S
- Ernlund, Amanda
- Rajasekhar, Vinagolu K
- Woolthuis, Carolien M
- Zhao, Guangjie
- Ha, Caryn J
- Schneider, Robert J
- Park, Christopher Y
DOIAbstract
The mechanisms that regulate protein synthesis in hematopoietic stem and progenitor cells (HSPCs) are poorly understood. Spevak, Elias, and colleagues provide a comprehensive characterization of the translatome in mouse HSPCs and show that mTOR- and CDK1-dependent mechanisms activate translation during distinct steps in hematopoietic development
Add to ORKG