The functional decline that is observed in HSCs upon aging is attributed mainly to cell intrinsic factors that regulate quiescence, self-renewal and differentiation. MicroRNAs (miRs) have an indispensable role in the regulation of HSCs and have been shown to also regulate processes related to tissue aging in specific cell types. Here we discuss the role of miRs in the regulation of HSC self-renewal and differentiation throughout life and its implications for future research
Human aging is associated with a decrease in tissue functions combined with a decline in stem cells ...
The preservation of hematopoieticstem cell pool in bone marrow (BM) is crucial for sustained hemato...
The ability to self-renew and to differentiate into at least one-cell lineage defines a stem cell. S...
The functional decline that is observed in HSCs upon aging is attributed mainly to cell intrinsic fa...
Aging is a biological process determined through time-related cellular and functional impairments, l...
Abstract Restoration of tissue homeostasis by controlling stem cell aging is a promising therapeutic...
miRNAs have been implicated in all stages of hematopoiesis including maintenance of self-renewal of ...
MicroRNAs are critical post-transcriptional regulators of hematopoietic cell-fate decisions, though ...
MicroRNAs are critical post-transcriptional regulators of hematopoietic cell-fate decisions, though ...
Peter van Galen focuses on understanding the determinants that maintain the stem cell state. Using h...
SummaryMicroRNAs are critical post-transcriptional regulators of hematopoietic cell-fate decisions, ...
Human ageing is a complex and integrated gradual deterioration of cellular processes. There are nine...
Hematopoietic stem cells (HSCs) are the adult stem cells in the bone marrow that are responsible for...
Ageing is among the main risk factors for human disease onset and the identification of the hallmark...
Human aging is associated with a decrease in tissue functions combined with a decline in stem cells ...
Human aging is associated with a decrease in tissue functions combined with a decline in stem cells ...
The preservation of hematopoieticstem cell pool in bone marrow (BM) is crucial for sustained hemato...
The ability to self-renew and to differentiate into at least one-cell lineage defines a stem cell. S...
The functional decline that is observed in HSCs upon aging is attributed mainly to cell intrinsic fa...
Aging is a biological process determined through time-related cellular and functional impairments, l...
Abstract Restoration of tissue homeostasis by controlling stem cell aging is a promising therapeutic...
miRNAs have been implicated in all stages of hematopoiesis including maintenance of self-renewal of ...
MicroRNAs are critical post-transcriptional regulators of hematopoietic cell-fate decisions, though ...
MicroRNAs are critical post-transcriptional regulators of hematopoietic cell-fate decisions, though ...
Peter van Galen focuses on understanding the determinants that maintain the stem cell state. Using h...
SummaryMicroRNAs are critical post-transcriptional regulators of hematopoietic cell-fate decisions, ...
Human ageing is a complex and integrated gradual deterioration of cellular processes. There are nine...
Hematopoietic stem cells (HSCs) are the adult stem cells in the bone marrow that are responsible for...
Ageing is among the main risk factors for human disease onset and the identification of the hallmark...
Human aging is associated with a decrease in tissue functions combined with a decline in stem cells ...
Human aging is associated with a decrease in tissue functions combined with a decline in stem cells ...
The preservation of hematopoieticstem cell pool in bone marrow (BM) is crucial for sustained hemato...
The ability to self-renew and to differentiate into at least one-cell lineage defines a stem cell. S...
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