The prognostic value of tumor mitotic rate in children and adolescents with cutaneous melanoma: A retrospective cohort study
- Ipenburg, Norbertus A.
- Lo, Serigne N.
- Vilain, Ricardo E.
- Holtkamp, Lodewijka H. J.
- Wilmott, James S.
- Nieweg, Omgo E.
- Thompson, John F.
- Scolyer, Richard A.
DOIAbstract
Background: Mitotic rate is a strong predictor of outcome in adult patients with primary cutaneous melanoma, but for children and adolescent patients this is unknown. Objective: We sought to assess the prognostic value of primary tumor mitotic rate in children and adolescents with primary melanoma. Methods: This was a cohort study of 156 patients who were <20 years of age and who had clinically localized cutaneous melanoma. Patients <12 years of age were classified as children and those 12 to 19 years of age as adolescents. Clinicopathologic and outcome data were collected. Recurrence-free and melanoma-specific survival were calculated. Univariable and multivariable analyses were performed using Cox proportional hazard models. Results: Thir...
Add to ORKG