Galectin-3 Coordinates a Cellular System for Lysosomal Repair and Removal
- Jia, Jingyue
- Claude-Taupin, Aurore
- Gu, Yuexi
- Choi, Seong Won
- Peters, Ryan
- Bissa, Bhawana
- Mudd, Michal H.
- Allers, Lee
- Pallikkuth, Sandeep
- Lidke, Keith A.
- Salemi, Michelle
- Phinney, Brett
- Mari, Muriel
- Reggiori, Fulvio
- Deretic, Vojo
DOIAbstract
Jia et al. show that Galectin-3 recruits ESCRT components to damaged lysosomes for repair and restoration of their function. During sustained lysosomal injury, galectins induce autophagy and lysosomal biogenesis for a staged repair, removal, and replacement program. This response is deployed during damage with neurotoxic tau or Mycobacterium tuberculosis infection
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