The complex microenvironment in which malignant tumor cells grow is crucial for cancer progression. The physical and biochemical characteristics of this niche are involved in controlling cancer cell differentiation, proliferation, invasion, and metastasis. It is therefore essential to understand how cancer cells interact and communicate with their surrounding tissue – the so-called tumor stroma – and how this interplay regulates disease progression. To mimic the tumor microenvironment (TME), 3D in vitro models are widely used because they can incorporate different patient-derived tissues/cells and allow longitudinal readouts, thus permitting deeper understanding of cell interactions. These models are therefore excellent tools to bridge the ...
Breast cancer is the most common cancer in women worldwide, and while screening, diagnostic tools an...
Anticancer drug discovery has long been hampered by the poor predictivity of the preclinical models....
Cancer is an evolving, dynamic, evasive and heterogeneous disease, characterized by high morbidity a...
The complex microenvironment in which malignant tumor cells grow is crucial for cancer progression. ...
Basic in vitro systems can be used to model and assess complex diseases, such as cancer. Recent adva...
The tumour microenvironment plays a critical role in tumour progression and drug resistance processe...
Three-dimensional (3D) cell cultures have recently garnered great attention because they promote lev...
Cancer occurs when cells acquire genomic instability and inflammation, produce abnormal levels of ep...
Three-dimensional (3D) in vitro models span the gap between two-dimensional cell cultures and whole-...
International audienceCancer is a complex disease and it is now clear that not only epithelial tumor...
The recent discovery of cancer stem cells (CSCs), or tumor initiating cells (TICs), in a variety of ...
Engineered tumor tissues carry promise as tools for making unique biological discoveries, as well as...
Contains fulltext : 139277.pdf (publisher's version ) (Closed access)Cancers are c...
Cancers are complex and heterogeneous pathological “organs” in a dynamic interplay with their host. ...
Tumor progression depends critically upon the interactions between the tumor cells and their microen...
Breast cancer is the most common cancer in women worldwide, and while screening, diagnostic tools an...
Anticancer drug discovery has long been hampered by the poor predictivity of the preclinical models....
Cancer is an evolving, dynamic, evasive and heterogeneous disease, characterized by high morbidity a...
The complex microenvironment in which malignant tumor cells grow is crucial for cancer progression. ...
Basic in vitro systems can be used to model and assess complex diseases, such as cancer. Recent adva...
The tumour microenvironment plays a critical role in tumour progression and drug resistance processe...
Three-dimensional (3D) cell cultures have recently garnered great attention because they promote lev...
Cancer occurs when cells acquire genomic instability and inflammation, produce abnormal levels of ep...
Three-dimensional (3D) in vitro models span the gap between two-dimensional cell cultures and whole-...
International audienceCancer is a complex disease and it is now clear that not only epithelial tumor...
The recent discovery of cancer stem cells (CSCs), or tumor initiating cells (TICs), in a variety of ...
Engineered tumor tissues carry promise as tools for making unique biological discoveries, as well as...
Contains fulltext : 139277.pdf (publisher's version ) (Closed access)Cancers are c...
Cancers are complex and heterogeneous pathological “organs” in a dynamic interplay with their host. ...
Tumor progression depends critically upon the interactions between the tumor cells and their microen...
Breast cancer is the most common cancer in women worldwide, and while screening, diagnostic tools an...
Anticancer drug discovery has long been hampered by the poor predictivity of the preclinical models....
Cancer is an evolving, dynamic, evasive and heterogeneous disease, characterized by high morbidity a...