Background & aims: Ageing is associated with an increased risk of frailty, intestinal microbiota perturbations, immunosenescence and oxidative stress. Prebiotics such as galacto-oligosaccharides (GOS) may ameliorate these ageing-related alterations. We aimed to compare the faecal microbiota composition, metabolite production, immune and oxidative stress markers in prefrail elderly and younger adults, and investigate the effects of GOS supplementation in both groups. Methods: In a randomised controlled cross-over study, 20 prefrail elderly and 24 healthy adults received 21.6 g/day Biotis™ GOS (containing 15.0 g/day GOS) or placebo. Faecal 16S rRNA gene-based microbiota and short-chain fatty acids were analysed at 0, 1 and 4 weeks of interven...
ObjectiveFrailty is a common geriatric syndrome that is diagnosed and staged based mainly on symptom...
Constipation is a major issue for 10–20% of the global population. In a double-blind randomized plac...
Abstract: Background: The human colon is colonised by a dense microbial community whose species comp...
Background & aims: Ageing is associated with an increased risk of frailty, intestinal microbiota...
It is recognised that ageing induces various changes to the human colonic microbiota. Most relevant ...
Faecal microbial changes associated with ageing include reduced bifidobacteria numbers. These change...
Background: Aging is associated with reduced numbers of beneficial colonic bifidobacteria and impair...
The ageing population in Europe is increasing, presenting society with potential medical and economi...
Elderly adults have alterations in their gut microbiota and immune functions that are associated wit...
International audienceBACKGROUND:Short-chain fructo-oligosaccharides (scFOS) are increasingly used i...
Background: Prebiotic galacto-oligosaccharides (GOS) have an extensively demonstrated beneficial imp...
Background & Aims: The gut microbiota affects host lipid and glucose metabolism, satiety, and chroni...
Globally increased life expectancy strongly triggered interest to delay the onset of frailty, which ...
Background: Nutritional supplements, such as bovine lactoferrin (bLF), have been studied for their i...
BACKGROUND: The human colon is colonised by a dense microbial community whose species composition an...
ObjectiveFrailty is a common geriatric syndrome that is diagnosed and staged based mainly on symptom...
Constipation is a major issue for 10–20% of the global population. In a double-blind randomized plac...
Abstract: Background: The human colon is colonised by a dense microbial community whose species comp...
Background & aims: Ageing is associated with an increased risk of frailty, intestinal microbiota...
It is recognised that ageing induces various changes to the human colonic microbiota. Most relevant ...
Faecal microbial changes associated with ageing include reduced bifidobacteria numbers. These change...
Background: Aging is associated with reduced numbers of beneficial colonic bifidobacteria and impair...
The ageing population in Europe is increasing, presenting society with potential medical and economi...
Elderly adults have alterations in their gut microbiota and immune functions that are associated wit...
International audienceBACKGROUND:Short-chain fructo-oligosaccharides (scFOS) are increasingly used i...
Background: Prebiotic galacto-oligosaccharides (GOS) have an extensively demonstrated beneficial imp...
Background & Aims: The gut microbiota affects host lipid and glucose metabolism, satiety, and chroni...
Globally increased life expectancy strongly triggered interest to delay the onset of frailty, which ...
Background: Nutritional supplements, such as bovine lactoferrin (bLF), have been studied for their i...
BACKGROUND: The human colon is colonised by a dense microbial community whose species composition an...
ObjectiveFrailty is a common geriatric syndrome that is diagnosed and staged based mainly on symptom...
Constipation is a major issue for 10–20% of the global population. In a double-blind randomized plac...
Abstract: Background: The human colon is colonised by a dense microbial community whose species comp...