Multiple functions of CD38 need exploring to expand clinical application of anti-CD38 antibodies in multiple myeloma (MM). We investigated membrane dynamics of MM cells and subsequent events when CD38 is targeted by therapeutic antibodies. Human MM cells (BF01) were co-cultured in vitro with therapeutic antibody (or control immunoglobulin G) and analysed using gene expression profiling. Microvesicles from antibody-exposed cells were analysed for differential gene and microRNA (miRNA) expression, and for phenotypic characterisation. Exposure of BF01 cells to anti-CD38 antibody resulted in CD38 membrane redistribution, upregulation of metabolism-related genes and downregulation of genes involved in cell cycle processes. Microvesicles derived ...
International audienceThe high CD38 expression by plasma cells together with the biological function...
Angiogenesis and immunosuppression promote multiple myeloma (MM) development, and osteolysis is a pr...
CD38, as a cell surface antigen is highly expressed in several hematologic malignancies including mu...
Multiple myeloma (MM) is a hematological disease characterized by the proliferation and accumulatio...
MM cells express high levels of CD38, while CD38 is expressed at relatively low levels on normal lym...
In the last decades CD38 has emerged as an attractive target for multiple myeloma (MM). CD38 is a no...
Abstract Background CD38 has been established as an important therapeutic target for multiple myelom...
CD38 is highly and uniformly expressed on multiple myeloma (MM) cells, and at relatively low levels ...
MM cells express high levels of CD38, while CD38 is expressed at relatively low levels on normal lym...
CD38 and B-cell maturation antigens (BCMAs) are prevalently expressed on neoplastic plasma cells in ...
: CD38 is a transmembrane glycoprotein with ectoenzymatic activity and is highly and uniformly expre...
Copyright © 2013 Giorgio Fedele et al. This is an open access article distributed under the Creative...
Monoclonal antibodies (mAbs) were initially considered as a possible "magic bullet" for in vivo elim...
Multiple myeloma (MM) is a tumor type characterized by the unregulated proliferation of clonal plasm...
International audienceMultiple myeloma (MM) is an incurable cancer characterized by the proliferatio...
International audienceThe high CD38 expression by plasma cells together with the biological function...
Angiogenesis and immunosuppression promote multiple myeloma (MM) development, and osteolysis is a pr...
CD38, as a cell surface antigen is highly expressed in several hematologic malignancies including mu...
Multiple myeloma (MM) is a hematological disease characterized by the proliferation and accumulatio...
MM cells express high levels of CD38, while CD38 is expressed at relatively low levels on normal lym...
In the last decades CD38 has emerged as an attractive target for multiple myeloma (MM). CD38 is a no...
Abstract Background CD38 has been established as an important therapeutic target for multiple myelom...
CD38 is highly and uniformly expressed on multiple myeloma (MM) cells, and at relatively low levels ...
MM cells express high levels of CD38, while CD38 is expressed at relatively low levels on normal lym...
CD38 and B-cell maturation antigens (BCMAs) are prevalently expressed on neoplastic plasma cells in ...
: CD38 is a transmembrane glycoprotein with ectoenzymatic activity and is highly and uniformly expre...
Copyright © 2013 Giorgio Fedele et al. This is an open access article distributed under the Creative...
Monoclonal antibodies (mAbs) were initially considered as a possible "magic bullet" for in vivo elim...
Multiple myeloma (MM) is a tumor type characterized by the unregulated proliferation of clonal plasm...
International audienceMultiple myeloma (MM) is an incurable cancer characterized by the proliferatio...
International audienceThe high CD38 expression by plasma cells together with the biological function...
Angiogenesis and immunosuppression promote multiple myeloma (MM) development, and osteolysis is a pr...
CD38, as a cell surface antigen is highly expressed in several hematologic malignancies including mu...