Rapid Molecular Tests for Influenza, Respiratory Syncytial Virus, and Other Respiratory Viruses : A Systematic Review of Diagnostic Accuracy and Clinical Impact Studies
- Vos, Laura M.
- Bruning, Andrea H.L.
- Reitsma, Johannes B.
- Schuurman, Rob
- Riezebos-Brilman, Annelies
- Hoepelman, Andy I.M.
- Oosterheert, Jan Jelrik
DOIAbstract
We systematically reviewed available evidence from Embase, Medline, and the Cochrane Library on diagnostic accuracy and clinical impact of commercially available rapid (results <3 hours) molecular diagnostics for respiratory viruses as compared to conventional molecular tests. Quality of included studies was assessed using the Quality Assessment of Diagnostic Accuracy Studies criteria for diagnostic test accuracy (DTA) studies, and the Cochrane Risk of Bias Assessment and Risk of Bias in Nonrandomized Studies of Interventions criteria for randomized and observational impact studies, respectively. Sixty-three DTA reports (56 studies) were meta-analyzed with a pooled sensitivity of 90.9% (95% confidence interval [CI], 88.7%-93.1%) and specifi...
Add to ORKG