Parental Occupational Exposure to Pesticides, Animals, and Organic Dust and Risk of Childhood Leukemia and Central Nervous System Tumors: Findings from the International Childhood Cancer Cohort Consortium (I4C)
- Patel, Deven M.
- Jones, Rena R.
- Booth, Benjamin J.
- Olsson, Ann C.
- Kromhout, Hans
- Straif, Kurt
- Vermeulen, Roel
- Tikellis, Gabriella
- Paltiel, Ora
- Golding, Jean
- Northstone, Kate
- Stoltenberg, Camilla
- Håberg, Siri E.
- Schüz, Joachim
- Friesen, Melissa C.
- Ponsonby, Anne‐Louise
- Lemeshow, Stanley
- Linet, Martha S.
- Magnus, Per
- Olsen, Jørn
- Olsen, Sjurdur F.
- Dwyer, Terence
- Stayner, Leslie T.
- Ward, Mary H.
- One Health Chemisch
- dIRAS RA-2
DOIAbstract
Parental occupational exposures to pesticides, animals and organic dust have been associated with an increased risk of childhood cancer based mostly on case-control studies. We prospectively evaluated parental occupational exposures and risk of childhood leukemia and central nervous system (CNS) tumors in the International Childhood Cancer Cohort Consortium. We pooled data on 329,658 participants from birth cohorts in five countries (Australia, Denmark, Israel, Norway and United Kingdom). Parental occupational exposures during pregnancy were estimated by linking International Standard Classification of Occupations-1988 job codes to the ALOHA+ job exposure matrix. Risk of childhood
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