Is treat-to-target really working in rheumatoid arthritis? a longitudinal analysis of a cohort of patients treated in daily practice (RA BIODAM)
- Ramiro, Sofia
- Landewé, Robert B. M.
- van der Heijde, D. sirée
- Sepriano, Alexandre
- Fitzgerald, Oliver
- Ostergaard, Mikkel
- Homik, Joanne
- Elkayam, Ori
- Thorne, J. Carter
- Larche, Margaret
- Ferraciolli, Gianfranco
- Backhaus, Marina
- Boire, Gilles
- Combe, Bernard
- Schaeverbeke, Thierry
- Saraux, Alain
- Dougados, Maxime
- Rossini, Maurizio
- Govoni, Marcello
- Sinigaglia, Luigi
- Cantagrel, Alain G.
- Allaart, Cornelia F.
- Barnabe, Cheryl
- Bingham, Clifton O.
- Tak, Paul P.
- van Schaardenburg, Dirkjan
- Hammer, Hilde Berner
- Dadashova, Rana
- Hutchings, Edna
- Paschke, Joel
- Maksymowych, Walter P.
DOIAbstract
Objectives To investigate whether following a treat-to-target (T2T)-strategy in daily clinical practice leads to more patients with rheumatoid arthritis (RA) meeting the remission target. Methods RA patients from 10 countries starting/changing conventional synthetic or biological disease-modifying anti-rheumatic drugs were assessed for disease activity every 3 months for 2 years (RA BIODAM (BIOmarkers of joint DAMage) cohort). Per visit was decided whether a patient was treated according to a T2T-strategy with 44-joint disease activity score (DAS44) remission (DAS44 <1.6) as the target. Sustained T2T was defined as T2T followed in ≥2 consecutive visits. The main outcome was the achievement of DAS44 remission at the subsequent 3-month visit....
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