Quantifying Duration of Proteinuria Remission and Association with Clinical Outcome in IgA Nephropathy
- Canney, M.
- Barbour, S.J.
- Zheng, Y.
- Coppo, R.
- Zhang, H
- Liu, Zhongjuan
- Matsuzaki, K.
- Suzuki, Y.
- Katafuchi, R.
- Wetzels, J.F.
- Steenbergen, E.
- Reich, H.N.
- Cattran, D.
DOIAbstract
BACKGROUND: On the basis of findings of observational studies and a meta-analysis, proteinuria reduction has been proposed as a surrogate outcome in IgA nephropathy. How long a reduction in proteinuria needs to be maintained to mitigate the long-term risk of disease progression is unknown. METHODS: In this retrospective multiethnic cohort of adult patients with IgA nephropathy, we defined proteinuria remission as a ≥25% reduction in proteinuria from the peak value after biopsy, and an absolute reduction in proteinuria to <1 g/d. The exposure of interest was the total duration of first remission, treated as a time-varying covariate using longitudinal proteinuria measurements. We used time-dependent Cox proportional hazards regression models ...
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