Extracellular matrix and β1 integrin expression in nodal and extranodal T-cell lymphomas

Since non-Hodgkin's lymphoma (NHL) cells interact with surrounding structures similarly to their normal counterparts, microenvironmental changes and the aberrant expression of adhesion molecules are considered to be of importance in lymphomagenesis. In this immunohistochemical study, the composition of several extracellular matrix (ECM) components and the expression of their β1 integrin receptors were examined in nodal and extranodal T-cell NHLs. Except for the T-lymphoblastic NHLs, almost all T-NHLs displayed abundant deposition of matrix and considerable expression of the α4 and β1 integrin chains. This is in contrast to B-cell NHLs, which show ECM patterns comparable to those in reactive lymphoid tissue or, in cases of high-grade malignancy, active matrix degradation and very low expression or absence of β1 integrins, as previously described. This difference is probably based on distinct cytokine production in B- and T-cell malignancies. As in B-NHL, nodal and extranodal T-NHLs of the same morphological subtype exhibit identical ECM patterns, which suggests that malignant lymphoid cells of both B and T origin create at least part of their own specific micro-environment