Survival of chronic lymphocytic leukemia (CLL) cells is mainly driven by interactions within the lymph node (LN) microenvironment with bystander cells such as T cells or cells from the monocytic lineage. Although the survival effect by T cells is largely governed by the TNFR ligand family member CD40L, the exact mechanism of monocyte-derived cell-induced survival is not known. An important role has been attributed to the TNFR ligand, a proliferation-inducing ligand (APRIL), although the exact mechanism remained unclear. Since we detected that APRIL was expressed by CD68+ cells in CLL LN, we addressed its relevance in various aspects of CLL biology, using a novel APRIL overexpressing co-culture system, recombinant APRIL, and APRIL reporter c...
The bone marrow (BM) is an organ extremely efficient in mediating long-term survival of plasma cells...
This work addresses the question whether CD38, a negative prognostic marker in B-cell chronic lympho...
Purpose: A proliferation-inducing ligand (APRIL), a tumor necrosis factor superfamily member involve...
We examined expression of B cell–activat-ing factor of the tumor necrosis factor (TNF) family (BAFF)...
Resistance to chemotherapy-induced cell death represents a major obstacle in the treatment of acute ...
The CLL tumor microenvironment contains cells and cytokines that support CLL survival. CD14+ monocyt...
Resistance to chemotherapy-induced cell death represents a major obstacle in the treatment of acute ...
A PRoliferation-Inducing TNF Ligand (APRIL) costimulates B-cell activation. When overexpressed in mi...
The role of monocytes/macrophages in the development and progression of chronic lymphocytic leukemia...
SummaryThe role of monocytes/macrophages in the development and progression of chronic lymphocytic l...
A PRoliferation-Inducing TNF Ligand (APRIL) costimulates B-cell activation. When overexpressed in mi...
Chronic lymphocytic leukemia (CLL) is hematopoietic malignancy involving clonal proliferation and ac...
AbstractA tumor-supporting role for the TNF-like ligand APRIL has been suggested. Here we describe t...
Tumor-infiltrating neutrophils have been implicated in malignant development and progression, but me...
Compelling evidence suggests that survival and proliferation of B-cell chronic lymphocytic leukemia ...
The bone marrow (BM) is an organ extremely efficient in mediating long-term survival of plasma cells...
This work addresses the question whether CD38, a negative prognostic marker in B-cell chronic lympho...
Purpose: A proliferation-inducing ligand (APRIL), a tumor necrosis factor superfamily member involve...
We examined expression of B cell–activat-ing factor of the tumor necrosis factor (TNF) family (BAFF)...
Resistance to chemotherapy-induced cell death represents a major obstacle in the treatment of acute ...
The CLL tumor microenvironment contains cells and cytokines that support CLL survival. CD14+ monocyt...
Resistance to chemotherapy-induced cell death represents a major obstacle in the treatment of acute ...
A PRoliferation-Inducing TNF Ligand (APRIL) costimulates B-cell activation. When overexpressed in mi...
The role of monocytes/macrophages in the development and progression of chronic lymphocytic leukemia...
SummaryThe role of monocytes/macrophages in the development and progression of chronic lymphocytic l...
A PRoliferation-Inducing TNF Ligand (APRIL) costimulates B-cell activation. When overexpressed in mi...
Chronic lymphocytic leukemia (CLL) is hematopoietic malignancy involving clonal proliferation and ac...
AbstractA tumor-supporting role for the TNF-like ligand APRIL has been suggested. Here we describe t...
Tumor-infiltrating neutrophils have been implicated in malignant development and progression, but me...
Compelling evidence suggests that survival and proliferation of B-cell chronic lymphocytic leukemia ...
The bone marrow (BM) is an organ extremely efficient in mediating long-term survival of plasma cells...
This work addresses the question whether CD38, a negative prognostic marker in B-cell chronic lympho...
Purpose: A proliferation-inducing ligand (APRIL), a tumor necrosis factor superfamily member involve...