Mycobacterium tuberculosis is responsible for almost 2 million deaths annually. Mycobacterium bovis bacillus Calmette-Guérin, the only vaccine available against tuberculosis (TB), induces highly variable protection against TB, and better TB vaccines are urgently needed. A prerequisite for candidate vaccine Ags is that they are immunogenic and expressed by M. tuberculosis during infection of the primary target organ, that is, the lungs of susceptible individuals. In search of new TB vaccine candidate Ags, we have used a genome-wide, unbiased Ag discovery approach to investigate the in vivo expression of 2170 M. tuberculosis genes during M. tuberculosis infection in the lungs of mice. Four genetically related but distinct mouse strains were s...
Objective(s): Tuberculosis (TB) has still remained a global health issue. One third of the world's p...
Abstract Background Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), infects ~8...
Tuberculosis still claims more lives than any other pathogen, and a vaccine better than BCG is urgen...
16 páginas, 8 figuras. Disponoble información suplementaria en: http://www.nature.com/srepNew strate...
Tuberculosis (TB) remains a life-threatening infectious disease of global proportions with serious n...
In view of the fact that only a small part of the Mtb expressome has been explored for identificatio...
Novel tuberculosis (TB)-vaccines preferably should (i) boost host immune responses induced by previo...
Bacillus Calmette-Guerin vaccine confers insufficient pulmonary protection against tuberculosis (TB)...
Every day Tuberculosis (TB) kills approximately three thousand people, a number that is on the rise ...
Tuberculosis (TB) is an infectious disease of international importance and ranks among the top 10 ca...
In spite of its highly immunogenic properties, Mycobacterium tuberculosis (Mtb) establishes persiste...
Human tuberculosis (TB) is caused by a plethora of Mycobacterium tuberculosis complex (MTBC) strains...
Background The continued increase in tuberculosis (TB) rates and the appearance of extremely resista...
Mycobacterium tuberculosis (M. tuberculosis), the causative agent of human tuberculosis (TB), is est...
Mycobacterium tuberculosis (M. tuberculosis), the causative agent of human tuberculosis (TB), is est...
Objective(s): Tuberculosis (TB) has still remained a global health issue. One third of the world's p...
Abstract Background Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), infects ~8...
Tuberculosis still claims more lives than any other pathogen, and a vaccine better than BCG is urgen...
16 páginas, 8 figuras. Disponoble información suplementaria en: http://www.nature.com/srepNew strate...
Tuberculosis (TB) remains a life-threatening infectious disease of global proportions with serious n...
In view of the fact that only a small part of the Mtb expressome has been explored for identificatio...
Novel tuberculosis (TB)-vaccines preferably should (i) boost host immune responses induced by previo...
Bacillus Calmette-Guerin vaccine confers insufficient pulmonary protection against tuberculosis (TB)...
Every day Tuberculosis (TB) kills approximately three thousand people, a number that is on the rise ...
Tuberculosis (TB) is an infectious disease of international importance and ranks among the top 10 ca...
In spite of its highly immunogenic properties, Mycobacterium tuberculosis (Mtb) establishes persiste...
Human tuberculosis (TB) is caused by a plethora of Mycobacterium tuberculosis complex (MTBC) strains...
Background The continued increase in tuberculosis (TB) rates and the appearance of extremely resista...
Mycobacterium tuberculosis (M. tuberculosis), the causative agent of human tuberculosis (TB), is est...
Mycobacterium tuberculosis (M. tuberculosis), the causative agent of human tuberculosis (TB), is est...
Objective(s): Tuberculosis (TB) has still remained a global health issue. One third of the world's p...
Abstract Background Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), infects ~8...
Tuberculosis still claims more lives than any other pathogen, and a vaccine better than BCG is urgen...