Olanzapine Versus Haloperidol for Treatment of Delirium in Patients with Advanced Cancer: A Phase III Randomized Clinical Trial
- van der Vorst, Maurice J.D.L.
- Neefjes, Elisabeth C.W.
- Boddaert, Manon S.A.
- Verdegaal, Bea A.T.T.
- Beeker, Aart
- Teunissen, Saskia C.C.
- Beekman, Aartjan T.F.
- Wilschut, Janneke A.
- Berkhof, Johannes
- Zuurmond, Wouter W.A.
- Verheul, Henk M.W.
DOIAbstract
Background: Treatment of delirium often includes haloperidol. Second-generation antipsychotics like olanzapine have emerged as an alternative with possibly fewer side effects. The aim of this multicenter, phase III, randomized clinical trial was to compare the efficacy and tolerability of olanzapine with haloperidol for the treatment of delirium in hospitalized patients with advanced cancer. Materials and Methods: Eligible adult patients (≥18 years) with advanced cancer and delirium (Delirium Rating Scale-Revised-98 [DRS-R-98] total score ≥17.75) were randomized 1:1 to receive either haloperidol or olanzapine (age-adjusted, titratable doses). Primary endpoint was delirium response rate (DRR), defined as number of patients with DRS-R-98 seve...
Add to ORKG