Meta-analyses of diagnostic test accuracy could not be reproduced

Background and Objectives: The aim of our study was to investigate the reproducibility of diagnostic accuracy meta-analyses, as reported in published systematic reviews. Study Design and Setting: We selected all systematic reviews of diagnostic test accuracy containing a meta-analysis, published in January 2018 and retrieved in Medline through Ovid. All reviews reported a summary estimate of sensitivity and specificity. We requested the protocol from their authors and used the protocol and the information in the published review to reproduce the reported meta-analysis. Successful reproduction was defined as a result differing