Add to ORKGThis dissertation describes the development of glyco-bioinformatics tools that facilitate the high-throughput data processing of glycomics and glycoproteomics experiments, specifically for both MALDI-TOF-MS (Chapter 2) and LC-ESI-MS (Chapter 3). The developed methods also provide various quality control parameters that assist the researcher in curating both the measured spectra and quantified analytes, thereby providing high-quality data in a high-throughput manner.The tools that were developed within this thesis have been used to identify the influence of glycosylation on trypsin efficacy of Immunoglobulin G (Chapter 3) and two biological cohorts. Specifically, to investigate the serum N-glycosylation during and after pregnancy (Chapter 5)...
The Human Proteome Organisation Human Disease Glycomics/Proteome Initiative recently coordinated a m...
The study of protein N-glycosylation is essential in biological and biopharmaceutical research as N-...
High-throughput methods to identify and quantify glycans in a given sample are rare. We have optimis...
This dissertation describes the development of glyco-bioinformatics tools that facilitate the high-t...
The study of N-linked glycosylation has long been complicated by a lack of bioinformatics tools. In ...
The study of N-linked glycosylation has long been complicated by a lack of bioinformatics tools. In ...
N-Glycosylation is a fundamentally important protein modification with a major impact on glycoprotei...
Experimental techniques to identify and quantify glycan structures in a given sample are continuousl...
Glycosylation is a post-translational modification (PTM) that exerts profound structural and functio...
Glycosylation is a key factor determining the pharmacological properties of biotherapeutics, includi...
Mass spectrometry (MS) of glycoproteins is an emerging field in proteomics, poised to meet the techn...
Analytical methods developed for studying immunoglobulin glycosylation rely heavily on software tail...
Glycosylation is a post-translational modification that enriches protein complexity and function. Dy...
A comprehensive glycan map was constructed for the top eight abundant glycoproteins in plasma using ...
Glycoproteomics is a powerful yet analytically challenging research tool. Software packages aiding t...
The Human Proteome Organisation Human Disease Glycomics/Proteome Initiative recently coordinated a m...
The study of protein N-glycosylation is essential in biological and biopharmaceutical research as N-...
High-throughput methods to identify and quantify glycans in a given sample are rare. We have optimis...
This dissertation describes the development of glyco-bioinformatics tools that facilitate the high-t...
The study of N-linked glycosylation has long been complicated by a lack of bioinformatics tools. In ...
The study of N-linked glycosylation has long been complicated by a lack of bioinformatics tools. In ...
N-Glycosylation is a fundamentally important protein modification with a major impact on glycoprotei...
Experimental techniques to identify and quantify glycan structures in a given sample are continuousl...
Glycosylation is a post-translational modification (PTM) that exerts profound structural and functio...
Glycosylation is a key factor determining the pharmacological properties of biotherapeutics, includi...
Mass spectrometry (MS) of glycoproteins is an emerging field in proteomics, poised to meet the techn...
Analytical methods developed for studying immunoglobulin glycosylation rely heavily on software tail...
Glycosylation is a post-translational modification that enriches protein complexity and function. Dy...
A comprehensive glycan map was constructed for the top eight abundant glycoproteins in plasma using ...
Glycoproteomics is a powerful yet analytically challenging research tool. Software packages aiding t...
The Human Proteome Organisation Human Disease Glycomics/Proteome Initiative recently coordinated a m...
The study of protein N-glycosylation is essential in biological and biopharmaceutical research as N-...
High-throughput methods to identify and quantify glycans in a given sample are rare. We have optimis...