Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited
- Deelen, J.
- Beekman, M.
- Uh, H.W.
- Helmer, Q.
- Kuningas, M.
- Christiansen, L.
- Kremer, D.
- Breggen, R. van der
- Suchiman, H.E.D.
- Lakenberg, N.
- Akker, E.B. van den
- Passtoors, W.M.
- Tiemeier, H.
- Heemst, D. van
- Craen, A.J. de
- Rivadeneira, F.
- Geus, E.J. de
- Perola, M.
- Ouderaa, F.J. van der
- Gunn, D.A.
- Boomsma, D.I.
- Uitterlinden, A.G.
- Christensen, K.
- Duijn, C.M. van
- Heijmans, B.T.
- Houwing-Duistermaat, J.J.
- Westendorp, R.G.J.
- Slagboom, P.E.
DOIAbstract
By studying the loci that contribute to human longevity, we aim to identify mechanisms that contribute to healthy aging. To identify such loci, we performed a genome-wide association study (GWAS) comparing 403 unrelated nonagenarians from long-living families included in the Leiden Longevity Study (LLS) and 1670 younger population controls. The strongest candidate SNPs from this GWAS have been analyzed in a meta-analysis of nonagenarian cases from the Rotterdam Study, Leiden 85-plus study, and Danish 1905 cohort. Only one of the 62 prioritized SNPs from the GWAS analysis (P < 1 x 10(-4)) showed genome-wide significance with survival into old age in the meta-analysis of 4149 nonagenarian cases and 7582 younger controls [OR = 0.71 (95% CI 0.6...
Add to ORKG