The role of inflammation in cardiovascular disease (CVD) is now widely accepted. Immune cells, including T cells, are influenced by inflammatory signals and contribute to the onset and progression of CVD. T cell activation is modulated by T cell co-stimulation and co-inhibition pathways. Immune checkpoint inhibitors (ICIs) targeting T cell inhibition pathways have revolutionized cancer treatment and improved survival in patients with cancer. However, ICIs might induce cardiovascular toxicity via T cell re-invigoration. With the rising use of ICIs for cancer treatment, a timely overview of the role of T cell co-stimulation and inhibition molecules in CVD is desirable. In this Review, the importance of these molecules in the pathogenesis of C...
Antibody-mediated blockade of co-inhibitory molecules such as cytotoxic T lymphocyte-associated prot...
Cardiovascular toxicities associated with immune checkpoint inhibitors (ICIs) have been reported in ...
Chimeric antigen receptor (CAR) T-cell and bispecific T-cell engager (BiTE) therapies have revolutio...
The role of inflammation in cardiovascular disease (CVD) is now widely accepted. Immune cells, inclu...
Immune checkpoint inhibitors (ICI) are monoclonal antibodies which bind to immune checkpoints (IC) a...
Background: Immunotherapy has revolutionized cancer treatment. However, immune checkpoint inhibitors...
Immunotherapy revolutionised oncology by harnessing the native immune system to effectively treat a ...
Immunotherapies have greatly expanded the armamentarium of cancer-directed therapies in the past dec...
International audienceAbstract Over the last decade or so, there has been a paradigm shift in the on...
Immune checkpoint inhibitor therapy has revolutionized the treatment of advanced malignancies in rec...
Immune-based therapies have revolutionized cancer treatments. Cardiovascular sequelae from these tre...
Antibody-mediated blockade of co-inhibitory molecules such as cytotoxic T lymphocyte-associated prot...
Adaptive immune response modulation has taken a central position in cancer therapy in recent decades...
Antibody-mediated blockade of co-inhibitory molecules such as cytotoxic T lymphocyte-associated prot...
Cardiovascular toxicities associated with immune checkpoint inhibitors (ICIs) have been reported in ...
Chimeric antigen receptor (CAR) T-cell and bispecific T-cell engager (BiTE) therapies have revolutio...
The role of inflammation in cardiovascular disease (CVD) is now widely accepted. Immune cells, inclu...
Immune checkpoint inhibitors (ICI) are monoclonal antibodies which bind to immune checkpoints (IC) a...
Background: Immunotherapy has revolutionized cancer treatment. However, immune checkpoint inhibitors...
Immunotherapy revolutionised oncology by harnessing the native immune system to effectively treat a ...
Immunotherapies have greatly expanded the armamentarium of cancer-directed therapies in the past dec...
International audienceAbstract Over the last decade or so, there has been a paradigm shift in the on...
Immune checkpoint inhibitor therapy has revolutionized the treatment of advanced malignancies in rec...
Immune-based therapies have revolutionized cancer treatments. Cardiovascular sequelae from these tre...
Antibody-mediated blockade of co-inhibitory molecules such as cytotoxic T lymphocyte-associated prot...
Adaptive immune response modulation has taken a central position in cancer therapy in recent decades...
Antibody-mediated blockade of co-inhibitory molecules such as cytotoxic T lymphocyte-associated prot...
Cardiovascular toxicities associated with immune checkpoint inhibitors (ICIs) have been reported in ...
Chimeric antigen receptor (CAR) T-cell and bispecific T-cell engager (BiTE) therapies have revolutio...