Generation of 5 induced pluripotent stem cell lines, LUMCi007-A and B and LUMCi008-A, B and C, from 2 patients with Huntington disease
- Graaf, L.M. van der
- Gardiner, S.L.
- Tok, M.
- Brands, T.
- Boogaard, M.W.
- Pepers, B.A.
- Eussen, B.
- Klein, A. de
- Aziz, N.A.
- Freund, C.
- Buijsen, R.A.M.
- Roon-Mom, W.M.C. van
DOIAbstract
Huntington disease (HD) is an autosomal dominant, neurodegenerative disease caused by a CAG repeat expansion within the coding sequence of the HTT gene, resulting in a highly toxic protein with an expanded polyglutamine stretch that forms typical protein aggregates throughout the brain. We generated human induced pluripotent stem cells (hiPSCs) from two HD patients using non-integrating Sendai virus (SeV). The hiPSCs display a normal karyotype, express all pluripotency markers, have the same CAG repeat expansion as the original fibroblasts and are able to differentiate into the three germ layers in vitro
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