Association of Birth Weight With Type 2 Diabetes and Glycemic Traits A Mendelian Randomization Study
- Huang, T.
- Wang, T.A.
- Zheng, Y.
- Ellervik, C.
- Li, X.
- Gao, M.
- Fang, Z.
- Chai, J.F.
- Ahluwalia, T.V.S.
- Wang, Y.J.
- Voortman, T.
- Noordam, R.
- Frazier-Wood, A.
- Scholz, M.
- Sonestedt, E.
- Akiyama, M.
- Dorajoo, R.
- Zhou, A.
- Kilpelainen, T.O.
- Kleber, M.E.
- Crozier, S.R.
- Godfrey, K.M.
- Lemaitre, R.
- Felix, J.F.
- Shi, Y.
- Gupta, P.
- Khor, C.C.
- Lehtimaki, T.
- Wang, C.A.
- Tiesler, C.M.T.
- Thiering, E.
- Standl, M.
- Rzehak, P.
- Marouli, E.
- He, M.
- Lecoeur, C.
- Corella, D.
- Lai, C.Q.
- Moreno, L.A.
- Pitkanen, N.
- Boreham, C.A.
- Zhang, T.
- Saw, S.M.
- Ridker, P.M.
- Graff, M.
- Rooij, F.J.A. van
- Uitterlinden, A.G.
- Hofman, A.
- Heemst, D. van
- Rosendaal, F.R.
- Mutsert, R. de
- Burkhardt, R.
- Schulz, C.A.
- Ericson, U.
- Kamatani, Y.
- Yuan, J.M.
- Power, C.
- Hansen, T.
- Sorensen, T.I.A.
- Tjonneland, A.
- Overvad, K.
- Delgado, G.
- Cooper, C.
- Djousse, L.
- Rivadeneira, F.
- Jameson, K.
- Zhao, W.
- Liu, J.J.
- Lee, N.R.
- Raitakari, O.
- Kahonen, M.
- Viikari, J.
- Grote, V.
- Langhendries, J.P.
- Koletzko, B.
- Escribano, J.
- Verduci, E.
- Dedoussis, G.
- Yu, C.Z.
- Tham, Y.C.
- Lim, B.
- Lim, S.H.
- Froguel, P.
- Balkau, B.
- Fink, N.R.
- Vinding, R.K.
- Sevelsted, A.
- Bisgaard, H.
- Coltell, O.
- Dallongeville, J.
- Gottrand, F.
- Pahkala, K.
- Niinikoski, H.
- Hypponen, E.
- Pedersen, O.
- Marz, W.
- Inskip, H.
- Jaddoe, V.V.
- Dennison, E.
- YinWong, T.
- Sabanayagam, C.
- Tai, E.S.
- Mohlke, K.L.
- Mackey, D.A.
- Gruszfeld, D.
- Deloukas, P.
- Tucker, K.L.
- Fumeron, F.
- Bonnelykke, K.
- Rossing, P.
- Estruch, R.
- Ordovas, J.M.
- Arnett, D.K.
- Meirhaeghe, A.
- Amouyel, P.
- Cheng, C.Y.
- Sim, X.L.
- Teo, Y.Y.
- Dam, R. van
- Koh, W.P.
- Orho-Melander, M.
- Loeffler, M.
- Kubo, M.
- Thiery, J.
- Mook-Kanamori, D.O.
- Mozaffarian, D.
- Psaty, B.M.
- Franco, O.H.
- Wu, T.C.
- North, K.E.
- Smith, G.D.
- Chavarro, J.E.
- Chasman, D.I.
- Qi, L.
- BIRTH-GENE BIG StudyWorking Grp
DOIAbstract
IMPORTANCE Observational studies have shown associations of birth weight with type 2 diabetes (T2D) and glycemic traits, but it remains unclear whether these associations represent causal associations.OBJECTIVE To test the association of birth weight with T2D and glycemic traits using a mendelian randomization analysis.DESIGN, SETTING, AND PARTICIPANTS This mendelian randomization study used a genetic risk score for birth weight that was constructed with 7 genome-wide significant single-nucleotide polymorphisms. The associations of this score with birth weight and T2D were tested in a mendelian randomization analysis using study-level data. The association of birth weight with T2D was tested using both study-level data (7 single-nucleotide ...
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