Type 2 diabetic patients are characterized by a decreased fat oxidative capacity and high levels of circulating free fatty acids (FFAs). The latter is known to cause insulin resistance, in particularly in skeletal muscle, by reducing insulin stimulated glucose uptake, most likely via accumulation of lipid inside the muscle cell. A reduced skeletal muscle oxidative capacity can exaggerate this. Furthermore, type 2 diabetes is associated with impaired metabolic flexibility, i.e. an impaired switching from fatty acid to glucose oxidation in response to insulin. Thus, a reduced fat oxidative capacity and metabolic inflexibility are important components of skeletal muscle insulin resistance. The cause of these derangements in skeletal muscle of ...
<div><p>Skeletal muscle resistance to insulin is related to accumulation of lipid-derived products, ...
SIGNIFICANCE: An early hallmark in the development of type 2 diabetes is the resistance to the effec...
National audienceIn modern societies, decreased physical activity, nutritional transition and aging ...
AB - Type 2 diabetic patients are characterized by a decreased fat oxidative capacity and high level...
Objective: Several lines of evidence support a potential role of skeletal muscle mitochondrial dysfu...
Mitochondrial dysfunction in skeletal muscle has been suggested to underlie the development of insul...
Skeletal muscle insulin resistance is a key contributor to the pathophysiology of type 2 diabetes. R...
Diabetes mellitus is a metabolic disorder resulting from defective insulin secretion, impaired insul...
Reduced mitochondrial capacity in skeletal muscle has been suggested to underlie the development of ...
Introduction: Mitochondrial dysfunction, lipid accumulation, insulin resistance and metabolic inflex...
PURPOSE OF REVIEW: Muscular mitochondrial dysfunction, leading to the accumulation of fat in skeleta...
<div><p>Skeletal muscle resistance to insulin is related to accumulation of lipid-derived products, ...
SIGNIFICANCE: An early hallmark in the development of type 2 diabetes is the resistance to the effec...
National audienceIn modern societies, decreased physical activity, nutritional transition and aging ...
AB - Type 2 diabetic patients are characterized by a decreased fat oxidative capacity and high level...
Objective: Several lines of evidence support a potential role of skeletal muscle mitochondrial dysfu...
Mitochondrial dysfunction in skeletal muscle has been suggested to underlie the development of insul...
Skeletal muscle insulin resistance is a key contributor to the pathophysiology of type 2 diabetes. R...
Diabetes mellitus is a metabolic disorder resulting from defective insulin secretion, impaired insul...
Reduced mitochondrial capacity in skeletal muscle has been suggested to underlie the development of ...
Introduction: Mitochondrial dysfunction, lipid accumulation, insulin resistance and metabolic inflex...
PURPOSE OF REVIEW: Muscular mitochondrial dysfunction, leading to the accumulation of fat in skeleta...
<div><p>Skeletal muscle resistance to insulin is related to accumulation of lipid-derived products, ...
SIGNIFICANCE: An early hallmark in the development of type 2 diabetes is the resistance to the effec...
National audienceIn modern societies, decreased physical activity, nutritional transition and aging ...