Determination of ciprofloxacin drug with molecularly imprinted polymer/co- metal organic framework nanofiber on modified glassy carbon electrode (GCE)

In this paper, we report the Co-metal organic frameworks (MOFs) were successfully synthesized with the aid of 2,6-pyridinedicarboxylic acid ammonium as an organic ligand in polylactic acid (PLA) as a biodegradable and biocompatibility polymer substrate through the ultrasonic-assisted electrospinning method. Co-MOFs/PLA nanofiber used as a new nanocomposite for design and construction of nanosensor based on the polymer prepared of the 4-aminobenzoic acid electrolytic molecule for measuring ciprofloxacin (CIP) drug class. The molecularly imprinted polymer (MIP) and non-imprinted polymer (NIP) sensors were studied by differential pulse voltammetry (DPV) to study changes in oxidation peaks and reduction of potassium ferricyanide. The calibration curve for ciprofloxacin was in the range of 0.5�150 μM also the detection limit was 0.017 μM and the standard deviation for five consecutive measurements at 60 μM concentration was calculated1.7 respectively. For characterizing the synthesized Co-MOF/PLA nanofiber we used X-ray diffraction (XRD), scanning electron microscopy (SEM), atomic force microscopy (AFM), energy dispersive spectroscopy (EDAX), Transmission electron microscopy (TEM) and Dynamic light scattering (DLS). In this study, we present new nanosensors with Co-MOF/PLA nanofiber as a biodegradable and bioactive composite for the first time in modified carbon paste electrode using the ultrasound-assisted direct micelle (UADM) method as the determination of ciprofloxacin drug. © 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature