Causal inference and American political development (APD) are widely separated and (to some) fundamentally incompatible tendencies within political science. In this paper, we explore points of connection between those two perspectives, while also highlighting differences that are not so easily bridged. We stress that both causal inference and APD are centrally interested in questions of causation, but they approach causation with very different ontological and epistemological commitments. We emphasize how the sort of detailed, contextualized, and often qualitative knowledge privileged by APD can promote credible causal (and descriptive) inferences, but also that scholars of causal inference can benefit from alternate conceptions of causalit...