Add to ORKGBackground: Major depressive disorder is associated with elevated levels of DNA oxidation, DNA damage, and gene expression of DNA repair enzymes including poly (ADP-ribose) polymerase-1 (PARP1). Elevated PARP1 activity is directly linked to neuroinflammation and PARP inhibitors are anti-inflammatory and neuroprotective. We previously showed that PARP inhibitors produce antidepressant-like effects equivalent to fluoxetine in rodent models. Here, we examined whether the PARP inhibitor 3-aminobenzamide (3AB) is effective in a rat model of treatment-resistant depression. Methods: Treatment-resistant depression was modeled with injections of lipopolysaccharide (LPS; 0.1 ug/kg/day) and daily chronic unpredictable stress (CUS) for 28 days. Anhed...
Evidence has accumulated suggesting that major depression is associated with dysfunction of inflamma...
Introduction - Major depression (MD) is a complex disease that originates from the interaction betwe...
Background: Rapid eye movement sleep deprivation (REMSD) and fluoxetine affect depression, yet the d...
Major depressive disorder (MDD) is a prevalent and enervating mental illness affecting millions glob...
Over 16 million people in the US suffer from major depressive disorder (MDD) each year. Approximatel...
The DNA base excision repair enzyme, poly(ADP-ribose) polymerase-1 (PARP1), is a multi-functional en...
Research has revealed that current antidepressant treatment is less than adequate at alleviating beh...
Major depressive disorder (MDD) is a leading cause of disability worldwide, with a lifetime prevalen...
Many patients suffering from depressive disorders are refractory to treatment with currently availab...
Background: Major depression with psychotic features presents with severe depressed mood and psychos...
Objective: Purinergic 2X7 receptor (P2X7R) activation is known to be involved in pathogenesis of dep...
Aims: Globally, depression is considered to be one of the leading causes of disability. Recently, it...
Major depression is a highly prevalent, multidimensional disorder. Although several classes of antid...
Major depression is a highly prevalent, multidimensional disorder. Although several classes of antid...
Background/Aims: Major depressive disorder is a common disease with serious morbidity, including inc...
Evidence has accumulated suggesting that major depression is associated with dysfunction of inflamma...
Introduction - Major depression (MD) is a complex disease that originates from the interaction betwe...
Background: Rapid eye movement sleep deprivation (REMSD) and fluoxetine affect depression, yet the d...
Major depressive disorder (MDD) is a prevalent and enervating mental illness affecting millions glob...
Over 16 million people in the US suffer from major depressive disorder (MDD) each year. Approximatel...
The DNA base excision repair enzyme, poly(ADP-ribose) polymerase-1 (PARP1), is a multi-functional en...
Research has revealed that current antidepressant treatment is less than adequate at alleviating beh...
Major depressive disorder (MDD) is a leading cause of disability worldwide, with a lifetime prevalen...
Many patients suffering from depressive disorders are refractory to treatment with currently availab...
Background: Major depression with psychotic features presents with severe depressed mood and psychos...
Objective: Purinergic 2X7 receptor (P2X7R) activation is known to be involved in pathogenesis of dep...
Aims: Globally, depression is considered to be one of the leading causes of disability. Recently, it...
Major depression is a highly prevalent, multidimensional disorder. Although several classes of antid...
Major depression is a highly prevalent, multidimensional disorder. Although several classes of antid...
Background/Aims: Major depressive disorder is a common disease with serious morbidity, including inc...
Evidence has accumulated suggesting that major depression is associated with dysfunction of inflamma...
Introduction - Major depression (MD) is a complex disease that originates from the interaction betwe...
Background: Rapid eye movement sleep deprivation (REMSD) and fluoxetine affect depression, yet the d...