Mevalonate kinase deficiency (MKD) is an autoinflammatory disease caused by recessive mutations in MVK. This gene encodes a metabolic enzyme in the mevalonate pathway of isoprenoid lipid biosynthesis, required for the process of protein prenylation. Mutations in MVK decrease isoprenoid synthesis and block prenylation, but also cause a build-up of mevalonic acid. How these lead to periodic fevers and inflammation in MKD remains unclear. Recent studies have suggested that lack of prenylation leads to assembly of the pyrin inflammasome, whilst others have shown that disruption of the mevalonate pathway triggers IL1β release via NLRP3 inflammasome activation. Lack of understanding of this disorder, and the absence of standardised treatment appr...
Deregulation of the mevalonate pathway is known to be involved in a number of diseases that exhibit ...
The mevalonate pathway, crucial for cholesterol synthesis, plays a key role in multiple cellular pro...
Mevalonate kinase (MK) deficiency is an autosomal recessive disorder, caused by mutations in the MVK...
Mevalonate kinase deficiency (MKD) is an autoinflammatory metabolic disorder characterized by life-l...
Mutations in the Mevalonate Kinase gene (MVK) are causes of a rare autoinflammatory disease: Mevalon...
Mevalonate Kinase Deficiency (MKD, OMIM #610377) is a rare autosomal recessive metabolic and inflamm...
The rare autoinflammatory disease mevalonate kinase deficiency (MKD, which includes HIDS and mevalon...
Mevalonate Kinase Deficiency (MKD), is a hereditary disease due to mutations in mevalonate kinase ge...
Inflammation is a highly regulated process involved both in the response to pathogens as well as in ...
Mevalonate kinase deficiency (MKD) is a rare hereditary auto-inflammatory syndrome due to mutations ...
Mevalonate kinase deficiency (MKD) is a rare autoinflammatory genetic disorder characterized by recu...
Mevalonate kinase deficiency (MKD) is a rare autosomal recessive autoinflammatory metabolic disease ...
Deregulation of the mevalonate pathway is known to be involved in a number of diseases that exhibit ...
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the ...
BACKGROUND: Mevalonate kinase deficiency (MKD) is a rare genetic autoinflammatory disease caused by ...
Deregulation of the mevalonate pathway is known to be involved in a number of diseases that exhibit ...
The mevalonate pathway, crucial for cholesterol synthesis, plays a key role in multiple cellular pro...
Mevalonate kinase (MK) deficiency is an autosomal recessive disorder, caused by mutations in the MVK...
Mevalonate kinase deficiency (MKD) is an autoinflammatory metabolic disorder characterized by life-l...
Mutations in the Mevalonate Kinase gene (MVK) are causes of a rare autoinflammatory disease: Mevalon...
Mevalonate Kinase Deficiency (MKD, OMIM #610377) is a rare autosomal recessive metabolic and inflamm...
The rare autoinflammatory disease mevalonate kinase deficiency (MKD, which includes HIDS and mevalon...
Mevalonate Kinase Deficiency (MKD), is a hereditary disease due to mutations in mevalonate kinase ge...
Inflammation is a highly regulated process involved both in the response to pathogens as well as in ...
Mevalonate kinase deficiency (MKD) is a rare hereditary auto-inflammatory syndrome due to mutations ...
Mevalonate kinase deficiency (MKD) is a rare autoinflammatory genetic disorder characterized by recu...
Mevalonate kinase deficiency (MKD) is a rare autosomal recessive autoinflammatory metabolic disease ...
Deregulation of the mevalonate pathway is known to be involved in a number of diseases that exhibit ...
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the ...
BACKGROUND: Mevalonate kinase deficiency (MKD) is a rare genetic autoinflammatory disease caused by ...
Deregulation of the mevalonate pathway is known to be involved in a number of diseases that exhibit ...
The mevalonate pathway, crucial for cholesterol synthesis, plays a key role in multiple cellular pro...
Mevalonate kinase (MK) deficiency is an autosomal recessive disorder, caused by mutations in the MVK...