Polymer-supported synthesis of a close analog (i.e. A) of an early lead, a 14- membered ring peptidomimetic D3, was described. The monovalent molecule was attached to different length linkers, and they were then paired sequentially on a triazine scaffold via our previously published methodology to give a small library of bivalent compounds 1 representing all combinations of linkers of the different lengths in a fast and efficient combinatorial manner. Cellular assays identified 1-ss as a TrkA receptor antagonist towards NGF and it was shown to bind TrkA with ~200 nM affinity and retains high selectivity towards TrkA in binding assays. A set of monovalent diketopiperazine (DKP) mimics 4-7 was synthesized efficiently from corresponding dipept...
The first part of this work involved the synthesis of chemical probes to the inhibition of the BfrB/...
The design and synthesis of a β-turn mimetic library as a key component of a small molecule library ...
Herein, we document our efforts to expand the scope of troponoid synthetic methodology towards dense...
Polymer-supported synthesis of a close analog (i.e. A) of an early lead, a 14- membered ring peptido...
Solid-phase syntheses of two 14-membered ring peptidomimetics were done to determine whether or not ...
Protein-protein interactions (PPIs) are attractive targets because of their therapeutic potential. ...
Through their use as mimics of post-translational modifications (PTMs) and in bioorthogonal chemical...
<div><p>A library of peptidomimetics was assembled combinatorially into dimers on a triazine-based c...
abstract: The manipulation of biological targets using synthetic compounds has been the focal point ...
The solid phase combinatorial method is an excellent tool for the modulation of protein-protein inte...
A grand challenge that crosses synthetic chemistry and biology is the scalable production of functio...
An efficient one-pot synthesis of Nα-protected S-linked 1,3,5-triazine tethered peptidomimetics is ...
Abstract s-Triazine-Based Self-Assembling Information Molecules Nature stores biological informat...
abstract: Small molecules have proven to be very important tools for exploration of biological syste...
Diverse dendrimer peripheries are often produced through convergent synthesis with multiple protecti...
The first part of this work involved the synthesis of chemical probes to the inhibition of the BfrB/...
The design and synthesis of a β-turn mimetic library as a key component of a small molecule library ...
Herein, we document our efforts to expand the scope of troponoid synthetic methodology towards dense...
Polymer-supported synthesis of a close analog (i.e. A) of an early lead, a 14- membered ring peptido...
Solid-phase syntheses of two 14-membered ring peptidomimetics were done to determine whether or not ...
Protein-protein interactions (PPIs) are attractive targets because of their therapeutic potential. ...
Through their use as mimics of post-translational modifications (PTMs) and in bioorthogonal chemical...
<div><p>A library of peptidomimetics was assembled combinatorially into dimers on a triazine-based c...
abstract: The manipulation of biological targets using synthetic compounds has been the focal point ...
The solid phase combinatorial method is an excellent tool for the modulation of protein-protein inte...
A grand challenge that crosses synthetic chemistry and biology is the scalable production of functio...
An efficient one-pot synthesis of Nα-protected S-linked 1,3,5-triazine tethered peptidomimetics is ...
Abstract s-Triazine-Based Self-Assembling Information Molecules Nature stores biological informat...
abstract: Small molecules have proven to be very important tools for exploration of biological syste...
Diverse dendrimer peripheries are often produced through convergent synthesis with multiple protecti...
The first part of this work involved the synthesis of chemical probes to the inhibition of the BfrB/...
The design and synthesis of a β-turn mimetic library as a key component of a small molecule library ...
Herein, we document our efforts to expand the scope of troponoid synthetic methodology towards dense...