Hydrogenases are efficient biocatalysts for H2 production and oxidation with various potential biotechnological applications.[NiFe]-class hydrogenases are highly active in both production and oxidation processes—albeit primarily biased to the latter—but suffer from being sensitive to O2.[NiFeSe] hydrogenases are a subclass of [NiFe] hydrogenases with, usually, an increased insensitivity to aerobic environments. In this study we aim to understand the structural causes of the low sensitivity of a [NiFeSe]-hydrogenase, when compared with a [NiFe] class enzyme, by studying the diffusion of O2. To unravel the differences between the two enzymes, we used computational methods comprising Molecular Dynamics simulations with explicit O2 and Implicit...
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. ...
The redox chemistry of the electron entry/exit site in Escherichia coli hydrogenase-1 is shown to pl...
International audienceWe propose a resolution to the paradox that spectroscopic studies of NiFeSe hy...
International audienceNature has evolved three different ways of metabolizing hydrogen, represented ...
AbstractHydrogenases catalyze the reversible oxidation of molecular hydrogen (H2), but little is kno...
AbstractHydrogenase proteins catalyze the reversible conversion of molecular hydrogen to protons and...
‘Oxygen-tolerant’ [NiFe]-hydrogenases can catalyze H2 oxidation under aerobic conditions, avoiding o...
Naturally occurring oxygen tolerant NiFe membrane bound hydrogenases have a conserved catalytic bias...
We studied the mechanism of aerobic inactivation of Desulfovibrio fructosovorans nickel-iron (NiFe) ...
Hydrogenases catalyse the interconversion of molecular hydrogen with protons and electrons. Thus, th...
Many promising hydrogen technologies utilising hydrogenase enzymes have been slowed by the fact that...
The tolerance towards oxic conditions of O2-tolerant [NiFe] hydrogenases has been attributed to an u...
International audienceSome NiFe hydrogenases are particularly resistant to O 2 , as a result of eith...
International audience[NiFe]-hydrogenases catalyse the cleavage of molecular hydrogen into protons a...
[NiFe] hydrogenases are enzymes that catalyze the splitting of molecular hydrogen according to the r...
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. ...
The redox chemistry of the electron entry/exit site in Escherichia coli hydrogenase-1 is shown to pl...
International audienceWe propose a resolution to the paradox that spectroscopic studies of NiFeSe hy...
International audienceNature has evolved three different ways of metabolizing hydrogen, represented ...
AbstractHydrogenases catalyze the reversible oxidation of molecular hydrogen (H2), but little is kno...
AbstractHydrogenase proteins catalyze the reversible conversion of molecular hydrogen to protons and...
‘Oxygen-tolerant’ [NiFe]-hydrogenases can catalyze H2 oxidation under aerobic conditions, avoiding o...
Naturally occurring oxygen tolerant NiFe membrane bound hydrogenases have a conserved catalytic bias...
We studied the mechanism of aerobic inactivation of Desulfovibrio fructosovorans nickel-iron (NiFe) ...
Hydrogenases catalyse the interconversion of molecular hydrogen with protons and electrons. Thus, th...
Many promising hydrogen technologies utilising hydrogenase enzymes have been slowed by the fact that...
The tolerance towards oxic conditions of O2-tolerant [NiFe] hydrogenases has been attributed to an u...
International audienceSome NiFe hydrogenases are particularly resistant to O 2 , as a result of eith...
International audience[NiFe]-hydrogenases catalyse the cleavage of molecular hydrogen into protons a...
[NiFe] hydrogenases are enzymes that catalyze the splitting of molecular hydrogen according to the r...
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. ...
The redox chemistry of the electron entry/exit site in Escherichia coli hydrogenase-1 is shown to pl...
International audienceWe propose a resolution to the paradox that spectroscopic studies of NiFeSe hy...