Add to ORKGThis project is aimed towards a better understanding of template-directed reactions and, based on this, towards the development of efficient non-enzymatic RNA replicating systems. These systems could serve as models for the prebiotic synthesis of an RNA world. The major objectives of this project were: (a) To elucidate the mechanistic aspects of template-directed (TD) chemistry, (b) to identify the conditions, environmental and other, that favor "organized chemistry" and stereo selective polymerization of nucleotides and (c) to search and, hopefully, find catalysts that will improve the efficiency of these reactions. Enhanced efficiency is expected to facilitate the road towards a self-replicating chemical system based on all four nucleic a...
In earlier work we have shown that C-rich templates containing isolated A, T or G residues and short...
AbstractA self-replicating RNA ligase ribozyme was converted to a cross-catalytic format whereby two...
The conventional synthesis of peptides, by reactions performed under highly concentrated conditions ...
We are investigating the reactions of ImpN's in the presence of a number of prebiotically plausible ...
Non-enzymatic, template-directed reactions have been proposed as models for prebiological polynucleo...
We describe the preparation of two monomers that bear complementary nucleobases at the edges (guanin...
In the past 30 years, the discovery of capabilities of nucleic acids far beyond their well-known inf...
The capability to transmit information from generation to generation is an essential feature of life...
textFunctional nucleic acids provide insight into the ‘RNA world,’ the proposed period in Earth’s hi...
The next challenge in synthetic biology is to be able to replicate synthetic nucleic acid sequences ...
The enzymatic polymerization of DNA and RNA is the basis for genetic inheritance for all living orga...
In the last 20 years there has been a number of synthetic and natural product based molecular replic...
Modern nucleic acid synthesizers utilize phosphite triester chemistries that employ stable phosphora...
Since the discovery of catalytic RNAs called ribozymes, there has been speculation that RNA was the ...
Threose nucleic acid (TNA) is a potential alternative genetic material that may have played a role i...
In earlier work we have shown that C-rich templates containing isolated A, T or G residues and short...
AbstractA self-replicating RNA ligase ribozyme was converted to a cross-catalytic format whereby two...
The conventional synthesis of peptides, by reactions performed under highly concentrated conditions ...
We are investigating the reactions of ImpN's in the presence of a number of prebiotically plausible ...
Non-enzymatic, template-directed reactions have been proposed as models for prebiological polynucleo...
We describe the preparation of two monomers that bear complementary nucleobases at the edges (guanin...
In the past 30 years, the discovery of capabilities of nucleic acids far beyond their well-known inf...
The capability to transmit information from generation to generation is an essential feature of life...
textFunctional nucleic acids provide insight into the ‘RNA world,’ the proposed period in Earth’s hi...
The next challenge in synthetic biology is to be able to replicate synthetic nucleic acid sequences ...
The enzymatic polymerization of DNA and RNA is the basis for genetic inheritance for all living orga...
In the last 20 years there has been a number of synthetic and natural product based molecular replic...
Modern nucleic acid synthesizers utilize phosphite triester chemistries that employ stable phosphora...
Since the discovery of catalytic RNAs called ribozymes, there has been speculation that RNA was the ...
Threose nucleic acid (TNA) is a potential alternative genetic material that may have played a role i...
In earlier work we have shown that C-rich templates containing isolated A, T or G residues and short...
AbstractA self-replicating RNA ligase ribozyme was converted to a cross-catalytic format whereby two...
The conventional synthesis of peptides, by reactions performed under highly concentrated conditions ...