Coxiella burnetii is an intracellular pathogen that can cause both acute and chronic disease (Q fever) in humans and infects many animals with varying clinical illness and persistence. A guinea pig aerosol-challenge model of acute Q fever was developed using infection with C. burnetii across a 5-log range of challenge doses. Clinical signs included fever, weight loss, respiratory difficulty, and death, with degree and duration of response corresponding to dose of organism delivered. Histopathologic evaluation revealed coalescing panleukocytic bronchointerstitial pneumonia 7 days after a high-dose challenge, resolving to multifocal lymphohistiocytic interstitial pneumonia by 28 days. Clinical and pathologic changes noted in these guinea pigs...
Coxiella burnetii, the causative agent of Q fever in humans, is a Gram-negative intracellular bacter...
Background: The recent outbreak of Q fever in the Netherlands between 2007 and 2009 is the largest r...
Coxiella burnetii, a Gram-negative intracellular bacterium, can give rise to Q fever in humans and i...
Coxiella burnetii is an intracellular pathogen that can cause both acute and chronic disease (Q feve...
Q fever is a zoonotic disease of worldwide significance caused by the obligate intracellular bacteri...
Coxiella burnetii, the aetiological agent of Q fever, causes acute, chronic or asymptomatic disease ...
Q fever is a zoonotic disease of worldwide significance caused by the obligate intracellular bacteri...
Coxiella burnetii is an intracellular, gram-negative bacterium that causes the zoonosis Q fever. Thi...
Coxiella burnetii is an obligate intracellular pathogen and the causative agent of the zoonotic illn...
Q fever is caused by the bacterium Coxiella burnetii and is spread to humans from infected animals e...
Q fever (coxiellosis) is an infectious disease of animals and humans, caused by.C. burnetii and wide...
Coxiella burnetii is an obligate intracellular Gram-negative bacterium and the causative agent of a ...
<p>Q fever is a worldwide zoonotic infectious disease caused by the bacterium Coxiella burnetii. Dur...
Q fever is a worldwide zoonosis caused by Coxiella burnetii. Human Q fever is typically acquired thr...
<p>Q-fever is a zoonosis caused by the gram-negative obligate intracellular pathogen Coxiella ...
Coxiella burnetii, the causative agent of Q fever in humans, is a Gram-negative intracellular bacter...
Background: The recent outbreak of Q fever in the Netherlands between 2007 and 2009 is the largest r...
Coxiella burnetii, a Gram-negative intracellular bacterium, can give rise to Q fever in humans and i...
Coxiella burnetii is an intracellular pathogen that can cause both acute and chronic disease (Q feve...
Q fever is a zoonotic disease of worldwide significance caused by the obligate intracellular bacteri...
Coxiella burnetii, the aetiological agent of Q fever, causes acute, chronic or asymptomatic disease ...
Q fever is a zoonotic disease of worldwide significance caused by the obligate intracellular bacteri...
Coxiella burnetii is an intracellular, gram-negative bacterium that causes the zoonosis Q fever. Thi...
Coxiella burnetii is an obligate intracellular pathogen and the causative agent of the zoonotic illn...
Q fever is caused by the bacterium Coxiella burnetii and is spread to humans from infected animals e...
Q fever (coxiellosis) is an infectious disease of animals and humans, caused by.C. burnetii and wide...
Coxiella burnetii is an obligate intracellular Gram-negative bacterium and the causative agent of a ...
<p>Q fever is a worldwide zoonotic infectious disease caused by the bacterium Coxiella burnetii. Dur...
Q fever is a worldwide zoonosis caused by Coxiella burnetii. Human Q fever is typically acquired thr...
<p>Q-fever is a zoonosis caused by the gram-negative obligate intracellular pathogen Coxiella ...
Coxiella burnetii, the causative agent of Q fever in humans, is a Gram-negative intracellular bacter...
Background: The recent outbreak of Q fever in the Netherlands between 2007 and 2009 is the largest r...
Coxiella burnetii, a Gram-negative intracellular bacterium, can give rise to Q fever in humans and i...