The domestic dog, Canis lupus familiaris, is a unique model system for the dissection of hereditary diseases. Selective breeding practices have created more than 300 distinct breeds of dogs, born from a desire to create specific physical and behavioral characteristics. Breeds represent closed breeding populations and the extensive records maintained for members of each breed (e.g., multi-generational pedigrees, veterinary medical records) present an incredible tool for genetic research. Two closed populations were used in the work presented here: a colony of mixed-breed dogs segregating resistance and sensitivity to cholesterol feeding, and a purebred pet population of Havanese experiencing a high frequency of developmental abnormalities. E...
Lauren Flynn ’21 Major: Biology and Mathematics Jordan Pagliuca ’21 Major: Biology Kathleen Kuhl ’22...
The domestic dog serves as an excellent model to investigate the genetic basis of disease. More than...
Dogs are the most phenotypically diverse mammalian species, and they possess more known heritable di...
The morphologic variability seen in the domestic dog, Canis lupus familiaris, is unique among mammal...
The domestic dog, Canis lupus familiaris, has emerged as a model system for the study of human hered...
Since the publication of the dog genome and the construction of high-quality genome- wide SNP arrays...
Knowledge on the genetic epidemiology of disorders in the dog population has implications for both v...
Knowledge on the genetic epidemiology of disorders in the dog population has implications for both v...
<div><p>Since the publication of the dog genome and the construction of high-quality genome-wide SNP...
Dogs provide an excellent model for human hereditary disease research; thus, the development of cani...
The domestic dog, Canis familiaris, has a unique population structure that lends itself to the study...
Humans and dogs share many common diseases, and it has been shown that the identification of mutatio...
Although typically thought of as a beloved companion or indispensable aide, the domestic dog (Canis ...
The Havanese is a toy breed that presents with a wide range of developmental abnormalities. Skeletal...
The domestic dog, Canis lupus familiaris, plays many roles in the lives of humans. Additionally, the...
Lauren Flynn ’21 Major: Biology and Mathematics Jordan Pagliuca ’21 Major: Biology Kathleen Kuhl ’22...
The domestic dog serves as an excellent model to investigate the genetic basis of disease. More than...
Dogs are the most phenotypically diverse mammalian species, and they possess more known heritable di...
The morphologic variability seen in the domestic dog, Canis lupus familiaris, is unique among mammal...
The domestic dog, Canis lupus familiaris, has emerged as a model system for the study of human hered...
Since the publication of the dog genome and the construction of high-quality genome- wide SNP arrays...
Knowledge on the genetic epidemiology of disorders in the dog population has implications for both v...
Knowledge on the genetic epidemiology of disorders in the dog population has implications for both v...
<div><p>Since the publication of the dog genome and the construction of high-quality genome-wide SNP...
Dogs provide an excellent model for human hereditary disease research; thus, the development of cani...
The domestic dog, Canis familiaris, has a unique population structure that lends itself to the study...
Humans and dogs share many common diseases, and it has been shown that the identification of mutatio...
Although typically thought of as a beloved companion or indispensable aide, the domestic dog (Canis ...
The Havanese is a toy breed that presents with a wide range of developmental abnormalities. Skeletal...
The domestic dog, Canis lupus familiaris, plays many roles in the lives of humans. Additionally, the...
Lauren Flynn ’21 Major: Biology and Mathematics Jordan Pagliuca ’21 Major: Biology Kathleen Kuhl ’22...
The domestic dog serves as an excellent model to investigate the genetic basis of disease. More than...
Dogs are the most phenotypically diverse mammalian species, and they possess more known heritable di...