Nowadays, Microelectronics industry must handle a real “data deluge” and a growing demand of added functionalities due to the new market sector of Internet Of Things, 5G but also Artificial Intelligence... At the same time, energy becomes a major issue and new computation paradigms emerge to break the traditional Von-Neumann architecture. In this context, this PhD manuscript explores both 3D monolithic integration and nano-electronic devices for In-Memory Computing. First, 3D monolithic integration is not seen only as an alternative to Moore’s law historic scaling but also to leverage circuit diversification. The advantages of this integration are analysed in depth and in particular an original top-tier Static Random Access Memories (SRAM) ...